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The metalloproteinase ADAM10 requires its activity to sustain surface expression.
Seifert A, Düsterhöft S, Wozniak J, Koo CZ, Tomlinson MG, Nuti E, Rossello A, Cuffaro D, Yildiz D, Ludwig A. Seifert A, et al. Among authors: koo cz. Cell Mol Life Sci. 2021 Jan;78(2):715-732. doi: 10.1007/s00018-020-03507-w. Epub 2020 May 5. Cell Mol Life Sci. 2021. PMID: 32372373 Free PMC article.
Tspan18 is a novel regulator of thrombo-inflammation.
Gavin RL, Koo CZ, Tomlinson MG. Gavin RL, et al. Among authors: koo cz. Med Microbiol Immunol. 2020 Aug;209(4):553-564. doi: 10.1007/s00430-020-00678-y. Epub 2020 May 23. Med Microbiol Immunol. 2020. PMID: 32447449 Free PMC article. Review.
The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex.
Koo CZ, Harrison N, Noy PJ, Szyroka J, Matthews AL, Hsia HE, Müller SA, Tüshaus J, Goulding J, Willis K, Apicella C, Cragoe B, Davis E, Keles M, Malinova A, McFarlane TA, Morrison PR, Nguyen HTH, Sykes MC, Ahmed H, Di Maio A, Seipold L, Saftig P, Cull E, Pliotas C, Rubinstein E, Poulter NS, Briddon SJ, Holliday ND, Lichtenthaler SF, Tomlinson MG. Koo CZ, et al. J Biol Chem. 2020 Sep 4;295(36):12822-12839. doi: 10.1074/jbc.RA120.012601. Epub 2020 Feb 28. J Biol Chem. 2020. PMID: 32111735 Free PMC article.
Tspan18 is a novel regulator of the Ca2+ channel Orai1 and von Willebrand factor release in endothelial cells.
Noy PJ, Gavin RL, Colombo D, Haining EJ, Reyat JS, Payne H, Thielmann I, Lokman AB, Neag G, Yang J, Lloyd T, Harrison N, Heath VL, Gardiner C, Whitworth KM, Robinson J, Koo CZ, Di Maio A, Harrison P, Lee SP, Michelangeli F, Kalia N, Rainger GE, Nieswandt B, Brill A, Watson SP, Tomlinson MG. Noy PJ, et al. Among authors: koo cz. Haematologica. 2019 Sep;104(9):1892-1905. doi: 10.3324/haematol.2018.194241. Epub 2018 Dec 20. Haematologica. 2019. PMID: 30573509 Free PMC article.