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Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals.
Elbere I, Silamikelis I, Ustinova M, Kalnina I, Zaharenko L, Peculis R, Konrade I, Ciuculete DM, Zhukovsky C, Gudra D, Radovica-Spalvina I, Fridmanis D, Pirags V, Schiöth HB, Klovins J. Elbere I, et al. Among authors: konrade i. Clin Epigenetics. 2018 Dec 13;10(1):156. doi: 10.1186/s13148-018-0593-x. Clin Epigenetics. 2018. PMID: 30545422 Free PMC article. Clinical Trial.
Evaluation of the Possibility to Detect Circulating Tumor DNA From Pituitary Adenoma.
Megnis K, Peculis R, Rovite V, Laksa P, Niedra H, Balcere I, Caune O, Breiksa A, Nazarovs J, Stukens J, Konrade I, Pirags V, Klovins J. Megnis K, et al. Among authors: konrade i. Front Endocrinol (Lausanne). 2019 Sep 18;10:615. doi: 10.3389/fendo.2019.00615. eCollection 2019. Front Endocrinol (Lausanne). 2019. PMID: 31620080 Free PMC article.
Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals.
Ustinova M, Silamikelis I, Kalnina I, Ansone L, Rovite V, Elbere I, Radovica-Spalvina I, Fridmanis D, Aladyeva J, Konrade I, Pirags V, Klovins J. Ustinova M, et al. Among authors: konrade i. PLoS One. 2019 Nov 8;14(11):e0224835. doi: 10.1371/journal.pone.0224835. eCollection 2019. PLoS One. 2019. PMID: 31703101 Free PMC article.
Case report: recurrent pituitary adenoma has increased load of somatic variants.
Peculis R, Balcere I, Radovica-Spalvina I, Konrade I, Caune O, Megnis K, Rovite V, Stukens J, Nazarovs J, Breiksa A, Kiecis A, Silamikelis I, Pirags V, Klovins J. Peculis R, et al. Among authors: konrade i. BMC Endocr Disord. 2020 Jan 29;20(1):17. doi: 10.1186/s12902-020-0493-x. BMC Endocr Disord. 2020. PMID: 31996211 Free PMC article.
Pituispheres Contain Genetic Variants Characteristic to Pituitary Adenoma Tumor Tissue.
Peculis R, Mandrika I, Petrovska R, Dortane R, Megnis K, Nazarovs J, Balcere I, Stukens J, Konrade I, Pirags V, Klovins J, Rovite V. Peculis R, et al. Among authors: konrade i. Front Endocrinol (Lausanne). 2020 May 22;11:313. doi: 10.3389/fendo.2020.00313. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 32528411 Free PMC article.
Baseline gut microbiome composition predicts metformin therapy short-term efficacy in newly diagnosed type 2 diabetes patients.
Elbere I, Silamikelis I, Dindune II, Kalnina I, Ustinova M, Zaharenko L, Silamikele L, Rovite V, Gudra D, Konrade I, Sokolovska J, Pirags V, Klovins J. Elbere I, et al. Among authors: konrade i. PLoS One. 2020 Oct 30;15(10):e0241338. doi: 10.1371/journal.pone.0241338. eCollection 2020. PLoS One. 2020. PMID: 33125401 Free PMC article.
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