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Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity.
Tsuneki H, Maeda T, Takata S, Sugiyama M, Otsuka K, Ishizuka H, Onogi Y, Tokai E, Koshida C, Kon K, Takasaki I, Hamashima T, Sasahara M, Rudich A, Koya D, Sakurai T, Yanagisawa M, Yamanaka A, Wada T, Sasaoka T. Tsuneki H, et al. Among authors: kon k. Cell Rep. 2022 Oct 18;41(3):111497. doi: 10.1016/j.celrep.2022.111497. Cell Rep. 2022. PMID: 36261021 Free article.
Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study.
Goldstein N, Tsuneki H, Bhandarkar N, Aimaretti E, Haim Y, Kon K, Sato K, Wada T, Liberty IF, Kirshtein B, Dukhno O, Maixner N, Gepner Y, Sasaoka T, Rudich A. Goldstein N, et al. Among authors: kon k. Obesity (Silver Spring). 2021 Nov;29(11):1857-1867. doi: 10.1002/oby.23262. Epub 2021 Sep 2. Obesity (Silver Spring). 2021. PMID: 34472713
N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health.
Hofer DC, Zirkovits G, Pelzmann HJ, Huber K, Pessentheiner AR, Xia W, Uno K, Miyazaki T, Kon K, Tsuneki H, Pendl T, Zoughbi WA, Madreiter-Sokolowski CT, Trausinger G, Abdellatif M, Schoiswohl G, Schreiber R, Eisenberg T, Magnes C, Sedej S, Eckhardt M, Sasahara M, Sasaoka T, Nitta A, Hoefler G, Graier WF, Kratky D, Auwerx J, Bogner-Strauss JG. Hofer DC, et al. Among authors: kon k. FASEB J. 2019 Dec;33(12):13808-13824. doi: 10.1096/fj.201801323R. Epub 2019 Nov 1. FASEB J. 2019. PMID: 31638418 Free PMC article.
Mechanistically, our data point to a possible role of NAA as modulator of pancreatic insulin secretion and suggest NAA as a critical energy metabolite for adipocyte and whole-body energy homeostasis.-Hofer, D. C., Zirkovits, G., Pelzmann, H. J., Huber, K., Pessentheiner, A …
Mechanistically, our data point to a possible role of NAA as modulator of pancreatic insulin secretion and suggest NAA as a critical energy …
[Topics in alcohol-associated/related liver disease].
Kon K. Kon K. Nihon Shokakibyo Gakkai Zasshi. 2024;121(5):365-370. doi: 10.11405/nisshoshi.121.365. Nihon Shokakibyo Gakkai Zasshi. 2024. PMID: 38735744 Review. Japanese. No abstract available.
248 results