Komura H - Search Results

1

Utilizing public and private sector data to build better machine learning models for the prediction of pharmacokinetic parameters.

Kuroda M, Watanabe R, Esaki T, Kawashima H, Ohashi R, Sato T, Honma T, Komura H, Mizuguchi K. Kuroda M, et al. Among authors: komura h. Drug Discov Today. 2022 Nov;27(11):103339. doi: 10.1016/j.drudis.2022.103339. Epub 2022 Aug 13. Drug Discov Today. 2022. PMID: 35973660 Free article.

2

A public-private partnership to enrich the development of in silico predictive models for pharmacokinetic and cardiotoxic properties.

Komura H, Watanabe R, Kawashima H, Ohashi R, Kuroda M, Sato T, Honma T, Mizuguchi K. Komura H, et al. Drug Discov Today. 2021 May;26(5):1275-1283. doi: 10.1016/j.drudis.2021.01.024. Epub 2021 Jan 28. Drug Discov Today. 2021. PMID: 33516857 Free article. Review.

3

Constructing an In Silico Three-Class Predictor of Human Intestinal Absorption With Caco-2 Permeability and Dried-DMSO Solubility.

Esaki T, Ohashi R, Watanabe R, Natsume-Kitatani Y, Kawashima H, Nagao C, Komura H, Mizuguchi K. Esaki T, et al. Among authors: komura h. J Pharm Sci. 2019 Nov;108(11):3630-3639. doi: 10.1016/j.xphs.2019.07.014. Epub 2019 Jul 25. J Pharm Sci. 2019. PMID: 31351866

4

Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration.

Watanabe R, Esaki T, Ohashi R, Kuroda M, Kawashima H, Komura H, Natsume-Kitatani Y, Mizuguchi K. Watanabe R, et al. Among authors: komura h. J Med Chem. 2021 Mar 11;64(5):2725-2738. doi: 10.1021/acs.jmedchem.0c02011. Epub 2021 Feb 23. J Med Chem. 2021. PMID: 33619967 Free article.

5

Development of a hybrid physiologically based pharmacokinetic model with drug-specific scaling factors in rat to improve prediction of human pharmacokinetics.

Sayama H, Komura H, Kogayu M, Iwaki M. Sayama H, et al. Among authors: komura h. J Pharm Sci. 2013 Nov;102(11):4193-204. doi: 10.1002/jps.23726. Epub 2013 Sep 9. J Pharm Sci. 2013. PMID: 24018828

Furthermore, we proposed a tiered approach using the three prediction methods, including the hybrid Dedrick approach, that were previously reported (Sayama H, Komura H, Kogayu M. 2013. Drug Metab Dispos 41:498-507), taking the available information in the ind …

Furthermore, we proposed a tiered approach using the three prediction methods, including the hybrid Dedrick approach, that were previously r …

6

Characterization of gastrointestinal absorption of digoxin involving influx and efflux transporter in rats: application of mdr1a knockout (-/-) rats into absorption study of multiple transporter substrate.

Suzuki M, Komura H, Yoshikawa T, Enya S, Nagao A, Takubo H, Kogayu M. Suzuki M, et al. Among authors: komura h. Xenobiotica. 2014 Nov;44(11):1039-45. doi: 10.3109/00498254.2014.920551. Epub 2014 May 19. Xenobiotica. 2014. PMID: 24839994

7

[High throughput screening of pharmacokinetics and metabolism in drug discovery (I)--establishment of assessment system for absorption to compounds with a wide diversity of physical properties].

Komura H, Kawahara I, Shigemoto Y, Matsuda K, Ano R, Murayama Y, Moriwaki T, Yoshida NH. Komura H, et al. Yakugaku Zasshi. 2005 Jan;125(1):121-30. doi: 10.1248/yakushi.125.121. Yakugaku Zasshi. 2005. PMID: 15635283 Free article. Japanese.

8

[High throughput screening of pharmacokinetics and metabolism in drug discovery (III)--investigation on in- silico model for membrane permeability and CYP1A2 inhibition].

Komura H, Shigemoto Y, Kawahara I, Matsuda K, Ano R, Murayama Y, Moriwaki T, Yoshida NH. Komura H, et al. Yakugaku Zasshi. 2005 Jan;125(1):141-7. doi: 10.1248/yakushi.125.141. Yakugaku Zasshi. 2005. PMID: 15635285 Free article. Japanese.

9

Species differences in in vitro and in vivo small intestinal metabolism of CYP3A substrates.

Komura H, Iwaki M. Komura H, et al. J Pharm Sci. 2008 May;97(5):1775-800. doi: 10.1002/jps.21121. J Pharm Sci. 2008. PMID: 17853429 Review.

10

Prediction of Hepatic Clearance of Stereoselective Metabolism of Carvedilol in Liver Microsomes and Hepatocytes of Sprague-Dawley and Cytochrome P450 2D-Deficient Dark Agouti Rats.

Iwaki M, Niwa T, Tanaka H, Kawase A, Komura H. Iwaki M, et al. Among authors: komura h. J Pharm Pharm Sci. 2019;22(1):72-84. doi: 10.18433/jpps30237. J Pharm Pharm Sci. 2019. PMID: 30678750 Free article.

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