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Deep generative modeling of the human proteome reveals over a hundred novel genes involved in rare genetic disorders.
Res Sq [Preprint]. 2024 Jan 4:rs.3.rs-3740259. doi: 10.21203/rs.3.rs-3740259/v1.
Res Sq. 2024.
PMID: 38260496
Free PMC article.
Preprint.
ProteinGym: Large-Scale Benchmarks for Protein Design and Fitness Prediction.
Notin P, Kollasch AW, Ritter D, van Niekerk L, Paul S, Spinner H, Rollins N, Shaw A, Weitzman R, Frazer J, Dias M, Franceschi D, Orenbuch R, Gal Y, Marks DS.
Notin P, et al. Among authors: kollasch aw.
bioRxiv [Preprint]. 2023 Dec 8:2023.12.07.570727. doi: 10.1101/2023.12.07.570727.
bioRxiv. 2023.
PMID: 38106144
Free PMC article.
Preprint.
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Deep generative modeling of the human proteome reveals over a hundred novel genes involved in rare genetic disorders.
Orenbuch R, Kollasch AW, Spinner HD, Shearer CA, Hopf TA, Franceschi D, Dias M, Frazer J, Marks DS.
Orenbuch R, et al. Among authors: kollasch aw.
medRxiv [Preprint]. 2023 Nov 28:2023.11.27.23299062. doi: 10.1101/2023.11.27.23299062.
medRxiv. 2023.
PMID: 38076790
Free PMC article.
Preprint.
Item in Clipboard
An ANXA11 P93S variant dysregulates TDP-43 and causes corticobasal syndrome.
Snyder A, Ryan VH, Hawrot J, Lawton S, Ramos DM, Qi YA, Johnson K, Reed X, Johnson NL, Kollasch AW, Duffy M, VandeVrede L, Cochran JN, Miller BL, Toro C, Bielekova B, Yokoyama JS, Marks DS, Kwan JY, Cookson MR, Ward ME.
Snyder A, et al. Among authors: kollasch aw.
Res Sq [Preprint]. 2023 Oct 19:rs.3.rs-3462973. doi: 10.21203/rs.3.rs-3462973/v1.
Res Sq. 2023.
PMID: 37886540
Free PMC article.
Preprint.
Item in Clipboard
Protein design and variant prediction using autoregressive generative models.
Shin JE, Riesselman AJ, Kollasch AW, McMahon C, Simon E, Sander C, Manglik A, Kruse AC, Marks DS.
Shin JE, et al. Among authors: kollasch aw.
Nat Commun. 2021 Apr 23;12(1):2403. doi: 10.1038/s41467-021-22732-w.
Nat Commun. 2021.
PMID: 33893299
Free PMC article.
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