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The stereochemistry of benzo[a]pyrene-2'-deoxyguanosine adducts affects DNA methylation by SssI and HhaI DNA methyltransferases.
Subach OM, Maltseva DV, Shastry A, Kolbanovskiy A, Klimasauskas S, Geacintov NE, Gromova ES. Subach OM, et al. Among authors: kolbanovskiy a. FEBS J. 2007 Apr;274(8):2121-34. doi: 10.1111/j.1742-4658.2007.05754.x. Epub 2007 Mar 27. FEBS J. 2007. PMID: 17388812 Free article.
The biologically most significant genotoxic metabolite of the environmental pollutant benzo[a]pyrene (B[a]P), (+)-7R,8S-diol 9S,10R-epoxide, reacts chemically with guanine in DNA, resulting in the predominant formation of (+)-trans-B[a]P-N(2)-dG and, to a
The biologically most significant genotoxic metabolite of the environmental pollutant benzo[a]pyrene (B[a]P), (+)-7R,8S-diol 9 …
Exocyclic amino groups of flanking guanines govern sequence-dependent adduct conformations and local structural distortions for minor groove-aligned benzo[a]pyrenyl-guanine lesions in a GG mutation hotspot context.
Rodríguez FA, Cai Y, Lin C, Tang Y, Kolbanovskiy A, Amin S, Patel DJ, Broyde S, Geacintov NE. Rodríguez FA, et al. Among authors: kolbanovskiy a. Nucleic Acids Res. 2007;35(5):1555-68. doi: 10.1093/nar/gkm022. Epub 2007 Feb 7. Nucleic Acids Res. 2007. PMID: 17287290 Free PMC article.
44 results