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HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice.
Uchida T, Imamura M, Hayes CN, Suehiro Y, Teraoka Y, Ohya K, Aikata H, Abe-Chayama H, Ishida Y, Tateno C, Hara Y, Hino K, Okamoto T, Matsuura Y, Aizaki H, Wake K, Kohara M, Liang TJ, Oka S, Chayama K. Uchida T, et al. Among authors: kohara m. Hepatology. 2023 Sep 1;78(3):929-942. doi: 10.1097/HEP.0000000000000335. Epub 2023 Mar 13. Hepatology. 2023. PMID: 36896966
Molecular insights of a CBP/β-catenin-signaling inhibitor on nonalcoholic steatohepatitis-induced liver fibrosis and disorder.
Yamaji K, Iwabuchi S, Tokunaga Y, Hashimoto S, Yamane D, Toyama S, Kono R, Kitab B, Tsukiyama-Kohara K, Osawa Y, Hayashi Y, Hishima T, Tateno C, Kimura K, Okanoue T, Kohara M. Yamaji K, et al. Among authors: kohara m. Biomed Pharmacother. 2023 Oct;166:115379. doi: 10.1016/j.biopha.2023.115379. Epub 2023 Aug 28. Biomed Pharmacother. 2023. PMID: 37647690 Free article.
Intranasal therapeutic vaccine containing HBsAg and HBcAg for patients with chronic hepatitis B; 18 months follow-up results of phase IIa clinical study.
Yoshida O, Akbar SMF, Imai Y, Sanada T, Tsukiyama-Kohara K, Miyazaki T, Kamishita T, Miyake T, Tokumoto Y, Hikita H, Tsuge M, Shimizu M, Al Mahtab M, Aguilar JC, Guillen G, Kohara M, Hiasa Y. Yoshida O, et al. Among authors: kohara m. Hepatol Res. 2023 Mar;53(3):196-207. doi: 10.1111/hepr.13851. Epub 2022 Nov 18. Hepatol Res. 2023. PMID: 36399406
A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor.
Furutani Y, Hirano Y, Toguchi M, Higuchi S, Qin XY, Yanaka K, Sato-Shiozaki Y, Takahashi N, Sakai M, Kongpracha P, Suzuki T, Dohmae N, Kukimoto-Niino M, Shirouzu M, Nagamori S, Suzuki H, Kobayashi K, Masaki T, Koyama H, Sekiba K, Otsuka M, Koike K, Kohara M, Kojima S, Kakeya H, Matsuura T. Furutani Y, et al. Among authors: kohara m. Cell Death Discov. 2023 Dec 22;9(1):467. doi: 10.1038/s41420-023-01755-w. Cell Death Discov. 2023. PMID: 38135680 Free PMC article.
A third dose of COVID-19 mRNA vaccine induces limited humoral response in stem cell transplant recipients who got two vaccine doses before transplant.
Toya T, Sadato D, Sanada T, Honda T, Atsuta Y, Sekiya N, Shimizu H, Najima Y, Kobayashi T, Harada Y, Kohara M, Doki N. Toya T, et al. Among authors: kohara m. EJHaem. 2022 Dec 22;4(1):309-11. doi: 10.1002/jha2.637. Online ahead of print. EJHaem. 2022. PMID: 36721642 Free PMC article. No abstract available.
Effects of neddylation on viral infection: an overview.
Kayesh MEH, Kohara M, Tsukiyama-Kohara K. Kayesh MEH, et al. Among authors: kohara m. Arch Virol. 2023 Dec 11;169(1):6. doi: 10.1007/s00705-023-05930-3. Arch Virol. 2023. PMID: 38081982 Review.
SARS-CoV-2 induces inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway in non-human primates.
Shimizu S, Nakayama M, Nguyen CT, Ishigaki H, Kitagawa Y, Yasui F, Yagi Y, Kusayanagi T, Kohara M, Itoh Y, Tojima I, Kouzaki H, Shimizu T. Shimizu S, et al. Among authors: kohara m. J Neuroimmunol. 2024 Feb 15;387:578288. doi: 10.1016/j.jneuroim.2024.578288. Epub 2024 Jan 8. J Neuroimmunol. 2024. PMID: 38237527 Free article.
An attenuated vaccinia vaccine encoding the severe acute respiratory syndrome coronavirus-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human angiotensin-converting enzyme 2 transgenic mice from severe acute respiratory syndrome coronavirus-2 and its variants.
Ishigaki H, Yasui F, Nakayama M, Endo A, Yamamoto N, Yamaji K, Nguyen CT, Kitagawa Y, Sanada T, Honda T, Munakata T, Higa M, Toyama S, Kono R, Takagi A, Matsumoto Y, Koseki A, Hayashi K, Shiohara M, Ishii K, Saeki Y, Itoh Y, Kohara M. Ishigaki H, et al. Among authors: kohara m. Front Microbiol. 2022 Nov 18;13:967019. doi: 10.3389/fmicb.2022.967019. eCollection 2022. Front Microbiol. 2022. PMID: 36466631 Free PMC article.
412 results