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Pharmacological inhibition of MEK1/2 signaling disrupts bile acid metabolism through loss of Shp and enhanced Cyp7a1 expression.
Verzijl CRC, van de Peppel IP, Eilers RE, Bloks VW, Wolters JC, Koehorst M, Kloosterhuis NJ, Havinga R, Jalving M, Struik D, Jonker JW. Verzijl CRC, et al. Among authors: koehorst m. Biomed Pharmacother. 2023 Mar;159:114270. doi: 10.1016/j.biopha.2023.114270. Epub 2023 Jan 19. Biomed Pharmacother. 2023. PMID: 36680812 Free article.
An early-life diet containing large phospholipid-coated lipid globules programmes later-life postabsorptive lipid trafficking in high-fat diet- but not in low-fat diet-fed mice.
Ronda OAHO, van de Heijning BJM, Martini IA, Koehorst M, Havinga R, Jurdzinski A, Bloks VW, van Dijk TH, van der Beek EM, Kuipers F, Verkade HJ. Ronda OAHO, et al. Among authors: koehorst m. Br J Nutr. 2021 May 14;125(9):961-971. doi: 10.1017/S0007114520002421. Epub 2020 Jul 3. Br J Nutr. 2021. PMID: 32616081
Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet.
Ronda OAHO, van de Heijning BJM, de Bruin A, Thomas RE, Martini I, Koehorst M, Gerding A, Koster MH, Bloks VW, Jurdzinski A, Mulder NL, Havinga R, van der Beek EM, Reijngoud DJ, Kuipers F, Verkade HJ. Ronda OAHO, et al. Among authors: koehorst m. PLoS One. 2020 Sep 21;15(9):e0232069. doi: 10.1371/journal.pone.0232069. eCollection 2020. PLoS One. 2020. PMID: 32956351 Free PMC article.
Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content.
Chen L, van den Munckhof ICL, Schraa K, Ter Horst R, Koehorst M, van Faassen M, van der Ley C, Doestzada M, Zhernakova DV, Kurilshikov A, Bloks VW, Groen AK; Human Functional Genomics Project; Riksen NP, Rutten JHW, Joosten LAB, Wijmenga C, Zhernakova A, Netea MG, Fu J, Kuipers F. Chen L, et al. Among authors: koehorst m. Cell Rep. 2020 Oct 6;33(1):108212. doi: 10.1016/j.celrep.2020.108212. Cell Rep. 2020. PMID: 33027657 Free article.
Cholangiopathy and Biliary Fibrosis in Cyp2c70-Deficient Mice Are Fully Reversed by Ursodeoxycholic Acid.
de Boer JF, de Vries HD, Palmiotti A, Li R, Doestzada M, Hoogerland JA, Fu J, La Rose AM, Westerterp M, Mulder NL, Hovingh MV, Koehorst M, Kloosterhuis NJ, Wolters JC, Bloks VW, Haas JT, Dombrowicz D, Staels B, van de Sluis B, Kuipers F. de Boer JF, et al. Among authors: koehorst m. Cell Mol Gastroenterol Hepatol. 2021;11(4):1045-1069. doi: 10.1016/j.jcmgh.2020.12.004. Epub 2020 Dec 10. Cell Mol Gastroenterol Hepatol. 2021. PMID: 33309945 Free PMC article.
38 results