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Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor.
Muratspahić E, Deibler K, Han J, Tomašević N, Jadhav KB, Olivé-Marti AL, Hochrainer N, Hellinger R, Koehbach J, Fay JF, Rahman MH, Hegazy L, Craven TW, Varga BR, Bhardwaj G, Appourchaux K, Majumdar S, Muttenthaler M, Hosseinzadeh P, Craik DJ, Spetea M, Che T, Baker D, Gruber CW. Muratspahić E, et al. Among authors: koehbach j. Nat Commun. 2023 Dec 6;14(1):8064. doi: 10.1038/s41467-023-43718-w. Nat Commun. 2023. PMID: 38052802 Free PMC article.
Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the κ-Opioid Receptor for the Treatment of Chronic Abdominal Pain.
Muratspahić E, Tomašević N, Koehbach J, Duerrauer L, Hadžić S, Castro J, Schober G, Sideromenos S, Clark RJ, Brierley SM, Craik DJ, Gruber CW. Muratspahić E, et al. Among authors: koehbach j. J Med Chem. 2021 Jul 8;64(13):9042-9055. doi: 10.1021/acs.jmedchem.1c00158. Epub 2021 Jun 23. J Med Chem. 2021. PMID: 34162205 Free PMC article.
Harnessing cyclotides to design and develop novel peptide GPCR ligands.
Muratspahić E, Koehbach J, Gruber CW, Craik DJ. Muratspahić E, et al. Among authors: koehbach j. RSC Chem Biol. 2020 Jul 22;1(4):177-191. doi: 10.1039/d0cb00062k. eCollection 2020 Oct 1. RSC Chem Biol. 2020. PMID: 34458757 Free PMC article. Review.
From ethnopharmacology to drug design.
Koehbach J, Gruber CW. Koehbach J, et al. Commun Integr Biol. 2013 Nov 1;6(6):e27583. doi: 10.4161/cib.27583. Epub 2014 Jan 8. Commun Integr Biol. 2013. PMID: 24567782 Free PMC article.
Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design.
Koehbach J, O'Brien M, Muttenthaler M, Miazzo M, Akcan M, Elliott AG, Daly NL, Harvey PJ, Arrowsmith S, Gunasekera S, Smith TJ, Wray S, Göransson U, Dawson PE, Craik DJ, Freissmuth M, Gruber CW. Koehbach J, et al. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21183-8. doi: 10.1073/pnas.1311183110. Epub 2013 Nov 18. Proc Natl Acad Sci U S A. 2013. PMID: 24248349 Free PMC article.
34 results