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Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans.
Espada L, Dakhovnik A, Chaudhari P, Martirosyan A, Miek L, Poliezhaieva T, Schaub Y, Nair A, Döring N, Rahnis N, Werz O, Koeberle A, Kirkpatrick J, Ori A, Ermolaeva MA. Espada L, et al. Among authors: koeberle a. Nat Metab. 2020 Nov;2(11):1316-1331. doi: 10.1038/s42255-020-00307-1. Epub 2020 Nov 2. Nat Metab. 2020. PMID: 33139960
Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome.
Werner M, Jordan PM, Romp E, Czapka A, Rao Z, Kretzer C, Koeberle A, Garscha U, Pace S, Claesson HE, Serhan CN, Werz O, Gerstmeier J. Werner M, et al. Among authors: koeberle a. FASEB J. 2019 May;33(5):6140-6153. doi: 10.1096/fj.201802509R. Epub 2019 Feb 8. FASEB J. 2019. PMID: 30735438 Free PMC article.
These and related enzymes act in conjunction with marked crosstalk within a complex lipid mediator (LM) network where also specialized proresolving LMs (SPMs) are formed. ...Our data may allow better appraisal of the therapeutic potential of these drugs to intervene with i …
These and related enzymes act in conjunction with marked crosstalk within a complex lipid mediator (LM) network where also specialize …
Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo.
Feisst C, Pergola C, Rakonjac M, Rossi A, Koeberle A, Dodt G, Hoffmann M, Hoernig C, Fischer L, Steinhilber D, Franke L, Schneider G, Rådmark O, Sautebin L, Werz O. Feisst C, et al. Among authors: koeberle a. Cell Mol Life Sci. 2009 Aug;66(16):2759-71. doi: 10.1007/s00018-009-0078-3. Epub 2009 Jul 5. Cell Mol Life Sci. 2009. PMID: 19579006
Total synthesis of myrtucommulone A.
Müller H, Paul M, Hartmann D, Huch V, Blaesius D, Koeberle A, Werz O, Jauch J. Müller H, et al. Among authors: koeberle a. Angew Chem Int Ed Engl. 2010 Mar 8;49(11):2045-9. doi: 10.1002/anie.200903906. Angew Chem Int Ed Engl. 2010. PMID: 20155764 No abstract available.
Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors.
Iranshahi M, Chini MG, Masullo M, Sahebkar A, Javidnia A, Chitsazian Yazdi M, Pergola C, Koeberle A, Werz O, Pizza C, Terracciano S, Piacente S, Bifulco G. Iranshahi M, et al. Among authors: koeberle a. J Nat Prod. 2015 Dec 24;78(12):2867-79. doi: 10.1021/acs.jnatprod.5b00700. Epub 2015 Nov 20. J Nat Prod. 2015. PMID: 26588603
123 results