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Rotational constriction of curcuminoids impacts 5-lipoxygenase and mPGES-1 inhibition and evokes a lipid mediator class switch in macrophages.
Rao Z, Caprioglio D, Gollowitzer A, Kretzer C, Imperio D, Collado JA, Waltl L, Lackner S, Appendino G, Muñoz E, Temml V, Werz O, Minassi A, Koeberle A. Rao Z, et al. Among authors: koeberle a. Biochem Pharmacol. 2022 Sep;203:115202. doi: 10.1016/j.bcp.2022.115202. Epub 2022 Aug 3. Biochem Pharmacol. 2022. PMID: 35932797 Free article.
Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators.
Peltner LK, Gluthmann L, Börner F, Pace S, Hoffstetter RK, Kretzer C, Bilancia R, Pollastro F, Koeberle A, Appendino G, Rossi A, Newcomer ME, Gilbert NC, Werz O, Jordan PM. Peltner LK, et al. Among authors: koeberle a. Cell Chem Biol. 2023 Dec 21;30(12):1508-1524.e7. doi: 10.1016/j.chembiol.2023.08.001. Epub 2023 Aug 29. Cell Chem Biol. 2023. PMID: 37647900
Tnfaip2/exoc3-driven lipid metabolism is essential for stem cell differentiation and organ homeostasis.
Deb S, Felix DA, Koch P, Deb MK, Szafranski K, Buder K, Sannai M, Groth M, Kirkpatrick J, Pietsch S, Gollowitzer A, Groß A, Riemenschneider P, Koeberle A, González-Estévez C, Rudolph KL. Deb S, et al. Among authors: koeberle a. EMBO Rep. 2021 Jan 7;22(1):e49328. doi: 10.15252/embr.201949328. Epub 2020 Dec 10. EMBO Rep. 2021. PMID: 33300287 Free PMC article.
PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling.
Thürmer M, Gollowitzer A, Pein H, Neukirch K, Gelmez E, Waltl L, Wielsch N, Winkler R, Löser K, Grander J, Hotze M, Harder S, Döding A, Meßner M, Troisi F, Ardelt M, Schlüter H, Pachmayr J, Gutiérrez-Gutiérrez Ó, Rudolph KL, Thedieck K, Schulze-Späte U, González-Estévez C, Kosan C, Svatoš A, Kwiatkowski M, Koeberle A. Thürmer M, et al. Among authors: koeberle a. Nat Commun. 2022 May 27;13(1):2982. doi: 10.1038/s41467-022-30374-9. Nat Commun. 2022. PMID: 35624087 Free PMC article.
123 results