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Cinnamamide derivatives with 4-hydroxypiperidine moiety enhance effect of doxorubicin to cancer cells and protect cardiomyocytes against drug-induced toxicity through CBR1 inhibition mechanism.
Koczurkiewicz-Adamczyk P, Gąsiorkiewicz B, Piska K, Gunia-Krzyżak A, Jamrozik M, Bucki A, Słoczyńska K, Bojdo P, Wójcik-Pszczoła K, Władyka B, Kołaczkowski M, Pękala E. Koczurkiewicz-Adamczyk P, et al. Life Sci. 2022 Sep 15;305:120777. doi: 10.1016/j.lfs.2022.120777. Epub 2022 Jul 2. Life Sci. 2022. PMID: 35792180
In silico and in vitro ADME-Tox analysis and in vivo pharmacokinetic study of representative pan-PDE inhibitors from the group of 7,8-disubstituted derivatives of 1,3-dimethyl-7H-purine-2,6-dione.
Wójcik-Pszczoła K, Szafarz M, Pociecha K, Słoczyńska K, Piska K, Koczurkiewicz-Adamczyk P, Kocot N, Chłoń-Rzepa G, Pękala E, Wyska E. Wójcik-Pszczoła K, et al. Among authors: koczurkiewicz adamczyk p. Toxicol Appl Pharmacol. 2022 Dec 15;457:116318. doi: 10.1016/j.taap.2022.116318. Epub 2022 Nov 19. Toxicol Appl Pharmacol. 2022. PMID: 36414119
Anticonvulsant and analgesic in neuropathic pain activity in a group of new aminoalkanol derivatives.
Pańczyk K, Rapacz A, Furgała-Wojas A, Sałat K, Koczurkiewicz-Adamczyk P, Łucjanek M, Skiba-Kurek I, Karczewska E, Sowa A, Żelaszczyk D, Siwek A, Popiół J, Pękala E, Marona H, Waszkielewicz A. Pańczyk K, et al. Bioorg Med Chem Lett. 2020 Aug 15;30(16):127325. doi: 10.1016/j.bmcl.2020.127325. Epub 2020 Jun 7. Bioorg Med Chem Lett. 2020. PMID: 32631530
Cinnamic acid derivatives as chemosensitising agents against DOX-treated lung cancer cells - Involvement of carbonyl reductase 1.
Koczurkiewicz-Adamczyk P, Piska K, Gunia-Krzyżak A, Bucki A, Jamrozik M, Lorenc E, Ryszawy D, Wójcik-Pszczoła K, Michalik M, Marona H, Kołaczkowski M, Pękala E. Koczurkiewicz-Adamczyk P, et al. Eur J Pharm Sci. 2020 Nov 1;154:105511. doi: 10.1016/j.ejps.2020.105511. Epub 2020 Aug 13. Eur J Pharm Sci. 2020. PMID: 32801001
27 results