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Synergistic anticancer activity of doxorubicin and piperlongumine on DU-145 prostate cancer cells - The involvement of carbonyl reductase 1 inhibition.
Piska K, Koczurkiewicz P, Wnuk D, Karnas E, Bucki A, Wójcik-Pszczoła K, Jamrozik M, Michalik M, Kołaczkowski M, Pękala E. Piska K, et al. Among authors: koczurkiewicz p. Chem Biol Interact. 2019 Feb 25;300:40-48. doi: 10.1016/j.cbi.2019.01.003. Epub 2019 Jan 3. Chem Biol Interact. 2019. PMID: 30611789
A dual-acting 5-HT6 receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties.
Canale V, Grychowska K, Kurczab R, Ryng M, Keeri AR, Satała G, Olejarz-Maciej A, Koczurkiewicz P, Drop M, Blicharz K, Piska K, Pękala E, Janiszewska P, Krawczyk M, Walczak M, Chaumont-Dubel S, Bojarski AJ, Marin P, Popik P, Zajdel P. Canale V, et al. Among authors: koczurkiewicz p. Eur J Med Chem. 2020 Dec 15;208:112765. doi: 10.1016/j.ejmech.2020.112765. Epub 2020 Aug 22. Eur J Med Chem. 2020. PMID: 32949963
Anticonvulsant activity, crystal structures, and preliminary safety evaluation of N-trans-cinnamoyl derivatives of selected (un)modified aminoalkanols.
Gunia-Krzyżak A, Żesławska E, Słoczyńska K, Koczurkiewicz P, Nitek W, Żelaszczyk D, Szkaradek N, Waszkielewicz AM, Pękala E, Marona H. Gunia-Krzyżak A, et al. Among authors: koczurkiewicz p. Eur J Med Chem. 2016 Jan 1;107:26-37. doi: 10.1016/j.ejmech.2015.10.051. Epub 2015 Nov 2. Eur J Med Chem. 2016. PMID: 26560050
Analgesic, antiallodynic, and anticonvulsant activity of novel hybrid molecules derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide in animal models of pain and epilepsy.
Rapacz A, Kamiński K, Obniska J, Koczurkiewicz P, Pękala E, Filipek B. Rapacz A, et al. Among authors: koczurkiewicz p. Naunyn Schmiedebergs Arch Pharmacol. 2017 Jun;390(6):567-579. doi: 10.1007/s00210-017-1358-3. Epub 2017 Feb 10. Naunyn Schmiedebergs Arch Pharmacol. 2017. PMID: 28188357 Free PMC article.
Metabolic carbonyl reduction of anthracyclines - role in cardiotoxicity and cancer resistance. Reducing enzymes as putative targets for novel cardioprotective and chemosensitizing agents.
Piska K, Koczurkiewicz P, Bucki A, Wójcik-Pszczoła K, Kołaczkowski M, Pękala E. Piska K, et al. Among authors: koczurkiewicz p. Invest New Drugs. 2017 Jun;35(3):375-385. doi: 10.1007/s10637-017-0443-2. Epub 2017 Mar 10. Invest New Drugs. 2017. PMID: 28283780 Free PMC article. Review.
Synthesis and Determination of Lipophilicity, Anticonvulsant Activity, and Preliminary Safety of 3-Substituted and 3-Unsubstituted N-[(4-Arylpiperazin-1-yl)alkyl]pyrrolidine-2,5-dione Derivatives.
Rybka S, Obniska J, Żmudzki P, Koczurkiewicz P, Wójcik-Pszczoła K, Pękala E, Bryła A, Rapacz A. Rybka S, et al. Among authors: koczurkiewicz p. ChemMedChem. 2017 Nov 22;12(22):1848-1856. doi: 10.1002/cmdc.201700539. Epub 2017 Nov 14. ChemMedChem. 2017. PMID: 29045762
46 results