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Antiviral efficacy against influenza virus and pharmacokinetic analysis of a novel MEK-inhibitor, ATR-002, in cell culture and in the mouse model.
Antiviral Res. 2020 Jun;178:104806. doi: 10.1016/j.antiviral.2020.104806. Epub 2020 Apr 15.
Antiviral Res. 2020.
PMID: 32304723
Free article.
Pharmacokinetics, Pharmacodynamics and Antiviral Efficacy of the MEK Inhibitor Zapnometinib in Animal Models and in Humans.
Koch-Heier J, Schönsiegel A, Waidele LM, Volk J, Füll Y, Wallasch C, Canisius S, Burnet M, Planz O.
Koch-Heier J, et al.
Front Pharmacol. 2022 Jun 15;13:893635. doi: 10.3389/fphar.2022.893635. eCollection 2022.
Front Pharmacol. 2022.
PMID: 35784712
Free PMC article.
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Inactivation of SARS-CoV-2 through Treatment with the Mouth Rinsing Solutions ViruProX® and BacterX® Pro.
Koch-Heier J, Hoffmann H, Schindler M, Lussi A, Planz O.
Koch-Heier J, et al.
Microorganisms. 2021 Mar 3;9(3):521. doi: 10.3390/microorganisms9030521.
Microorganisms. 2021.
PMID: 33802603
Free PMC article.
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Influenza A virus replication has a stronger dependency on Raf/MEK/ERK signaling pathway activity than SARS-CoV-2.
Hoffmann H, Ebensperger M, Schönsiegel A, Hamza H, Koch-Heier J, Schreiber A, Ludwig S, Schindler M, Planz O.
Hoffmann H, et al. Among authors: koch heier j.
Front Cell Infect Microbiol. 2023 Oct 26;13:1264983. doi: 10.3389/fcimb.2023.1264983. eCollection 2023.
Front Cell Infect Microbiol. 2023.
PMID: 37965261
Free PMC article.
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Establishment of a novel method to assess MEK1/2 inhibition in PBMCs for clinical drug development.
Schüssele LM, Koch-Heier J, Volk J, Löffler MW, Hoffmann K, Bruyns RM, Planz O.
Schüssele LM, et al. Among authors: koch heier j.
Front Cell Dev Biol. 2022 Dec 12;10:1063692. doi: 10.3389/fcell.2022.1063692. eCollection 2022.
Front Cell Dev Biol. 2022.
PMID: 36578787
Free PMC article.
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