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Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation.
Stratton MS, Bagchi RA, Felisbino MB, Hirsch RA, Smith HE, Riching AS, Enyart BY, Koch KA, Cavasin MA, Alexanian M, Song K, Qi J, Lemieux ME, Srivastava D, Lam MPY, Haldar SM, Lin CY, McKinsey TA. Stratton MS, et al. Among authors: koch ka. Circ Res. 2019 Sep 13;125(7):662-677. doi: 10.1161/CIRCRESAHA.119.315125. Epub 2019 Aug 14. Circ Res. 2019. PMID: 31409188 Free PMC article.
p38α: A Profibrotic Signaling Nexus.
Stratton MS, Koch KA, McKinsey TA. Stratton MS, et al. Among authors: koch ka. Circulation. 2017 Aug 8;136(6):562-565. doi: 10.1161/CIRCULATIONAHA.117.028957. Circulation. 2017. PMID: 28784825 Free PMC article. No abstract available.
Cortical bone stem cells modify cardiac inflammation after myocardial infarction by inducing a novel macrophage phenotype.
Hobby ARH, Berretta RM, Eaton DM, Kubo H, Feldsott E, Yang Y, Headrick AL, Koch KA, Rubino M, Kurian J, Khan M, Tan Y, Mohsin S, Gallucci S, McKinsey TA, Houser SR. Hobby ARH, et al. Among authors: koch ka. Am J Physiol Heart Circ Physiol. 2021 Oct 1;321(4):H684-H701. doi: 10.1152/ajpheart.00304.2021. Epub 2021 Aug 20. Am J Physiol Heart Circ Physiol. 2021. PMID: 34415185 Free PMC article.
Cortical bone stem cell-derived exosomes' therapeutic effect on myocardial ischemia-reperfusion and cardiac remodeling.
Schena GJ, Murray EK, Hildebrand AN, Headrick AL, Yang Y, Koch KA, Kubo H, Eaton D, Johnson J, Berretta R, Mohsin S, Kishore R, McKinsey TA, Elrod JW, Houser SR. Schena GJ, et al. Among authors: koch ka. Am J Physiol Heart Circ Physiol. 2021 Dec 1;321(6):H1014-H1029. doi: 10.1152/ajpheart.00197.2021. Epub 2021 Oct 8. Am J Physiol Heart Circ Physiol. 2021. PMID: 34623184 Free PMC article.
Inhibition of Eicosanoid Degradation Mitigates Fibrosis of the Heart.
Rubino M, Travers JG, Headrick AL, Enyart BT, Lemieux ME, Cavasin MA, Schwisow JA, Hardy EJ, Kaltenbacher KJ, Felisbino MB, Jonas E, Ambardekar AV, Bristow MR, Koch KA, McKinsey TA. Rubino M, et al. Among authors: koch ka. Circ Res. 2023 Jan 6;132(1):10-29. doi: 10.1161/CIRCRESAHA.122.321475. Epub 2022 Dec 8. Circ Res. 2023. PMID: 36475698 Free article.
Suppression of HDAC nuclear export and cardiomyocyte hypertrophy by novel irreversible inhibitors of CRM1.
Monovich L, Koch KA, Burgis R, Osimboni E, Mann T, Wall D, Gao J, Feng Y, Vega RB, Turner BA, Hood DB, Law A, Papst PJ, Koditek D, Chapo JA, Reid BG, Melvin LS, Pagratis NC, McKinsey TA. Monovich L, et al. Among authors: koch ka. Biochim Biophys Acta. 2009 May;1789(5):422-31. doi: 10.1016/j.bbagrm.2009.04.001. Epub 2009 May 3. Biochim Biophys Acta. 2009. PMID: 19414071
Identification of orally available naphthyridine protein kinase D inhibitors.
Meredith EL, Ardayfio O, Beattie K, Dobler MR, Enyedy I, Gaul C, Hosagrahara V, Jewell C, Koch K, Lee W, Lehmann H, McKinsey TA, Miranda K, Pagratis N, Pancost M, Patnaik A, Phan D, Plato C, Qian M, Rajaraman V, Rao C, Rozhitskaya O, Ruppen T, Shi J, Siska SJ, Springer C, van Eis M, Vega RB, von Matt A, Yang L, Yoon T, Zhang JH, Zhu N, Monovich LG. Meredith EL, et al. J Med Chem. 2010 Aug 12;53(15):5400-21. doi: 10.1021/jm100075z. J Med Chem. 2010. PMID: 20684591
Identification of potent and selective amidobipyridyl inhibitors of protein kinase D.
Meredith EL, Beattie K, Burgis R, Capparelli M, Chapo J, Dipietro L, Gamber G, Enyedy I, Hood DB, Hosagrahara V, Jewell C, Koch KA, Lee W, Lemon DD, McKinsey TA, Miranda K, Pagratis N, Phan D, Plato C, Rao C, Rozhitskaya O, Soldermann N, Springer C, van Eis M, Vega RB, Yan W, Zhu Q, Monovich LG. Meredith EL, et al. Among authors: koch ka. J Med Chem. 2010 Aug 12;53(15):5422-38. doi: 10.1021/jm100076w. J Med Chem. 2010. PMID: 20684592
78 results