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ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness.
Koyasu S, Horita S, Saito K, Kobayashi M, Ishikita H, Chow CC, Kambe G, Nishikawa S, Menju T, Morinibu A, Okochi Y, Tabuchi Y, Onodera Y, Takeda N, Date H, Semenza GL, Hammond EM, Harada H. Koyasu S, et al. Among authors: kobayashi m. EMBO Rep. 2023 Jan 9;24(1):e54042. doi: 10.15252/embr.202154042. Epub 2022 Nov 7. EMBO Rep. 2023. PMID: 36341521 Free PMC article.
[Hypoxic stress and HIF].
Kobayashi M, Harada H. Kobayashi M, et al. Seikagaku. 2013 Mar;85(3):187-95. Seikagaku. 2013. PMID: 23631314 Review. Japanese. No abstract available.
UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α.
Goto Y, Zeng L, Yeom CJ, Zhu Y, Morinibu A, Shinomiya K, Kobayashi M, Hirota K, Itasaka S, Yoshimura M, Tanimoto K, Torii M, Sowa T, Menju T, Sonobe M, Kakeya H, Toi M, Date H, Hammond EM, Hiraoka M, Harada H. Goto Y, et al. Among authors: kobayashi m. Nat Commun. 2015 Jan 23;6:6153. doi: 10.1038/ncomms7153. Nat Commun. 2015. PMID: 25615526 Free PMC article.
The emerging roles of the ubiquitination/deubiquitination system in tumor radioresistance regarding DNA damage responses, cell cycle regulation, hypoxic responses, and antioxidant properties: Insight into the development of novel radiosensitizing strategies.
Goto Y, Koyasu S, Kobayashi M, Harada H. Goto Y, et al. Among authors: kobayashi m. Mutat Res. 2017 Oct;803-805:76-81. doi: 10.1016/j.mrfmmm.2017.07.007. Epub 2017 Jul 22. Mutat Res. 2017. PMID: 28778421 Review.
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