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Page 1
Elovl6 promotes nonalcoholic steatohepatitis.
Matsuzaka T, Atsumi A, Matsumori R, Nie T, Shinozaki H, Suzuki-Kemuriyama N, Kuba M, Nakagawa Y, Ishii K, Shimada M, Kobayashi K, Yatoh S, Takahashi A, Takekoshi K, Sone H, Yahagi N, Suzuki H, Murata S, Nakamuta M, Yamada N, Shimano H. Matsuzaka T, et al. Among authors: kobayashi k. Hepatology. 2012 Dec;56(6):2199-208. doi: 10.1002/hep.25932. Hepatology. 2012. PMID: 22753171
Macrophage Elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.
Saito R, Matsuzaka T, Karasawa T, Sekiya M, Okada N, Igarashi M, Matsumori R, Ishii K, Nakagawa Y, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Sone H, Suzuki H, Yahagi N, Yamada N, Shimano H. Saito R, et al. Among authors: kobayashi k. Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):1973-9. doi: 10.1161/ATVBAHA.110.221663. Epub 2011 Aug 4. Arterioscler Thromb Vasc Biol. 2011. PMID: 21817094
Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion.
Tang N, Matsuzaka T, Suzuki M, Nakano Y, Zao H, Yokoo T, Suzuki-Kemuriyama N, Kuba M, Okajima Y, Takeuchi Y, Kobayashi K, Iwasaki H, Yatoh S, Takahashi A, Suzuki H, Sone H, Shimada M, Nakagawa Y, Yahagi N, Yamada N, Shimano H. Tang N, et al. Among authors: kobayashi k. Biochem Biophys Res Commun. 2014 Jul 18;450(1):318-23. doi: 10.1016/j.bbrc.2014.05.113. Epub 2014 Jun 2. Biochem Biophys Res Commun. 2014. PMID: 24938128
Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model.
Kuba M, Matsuzaka T, Matsumori R, Saito R, Kaga N, Taka H, Ikehata K, Okada N, Kikuchi T, Ohno H, Han SI, Takeuchi Y, Kobayashi K, Iwasaki H, Yatoh S, Suzuki H, Sone H, Yahagi N, Arakawa Y, Fujimura T, Nakagawa Y, Yamada N, Shimano H. Kuba M, et al. Among authors: kobayashi k. Sci Rep. 2015 Dec 1;5:17604. doi: 10.1038/srep17604. Sci Rep. 2015. PMID: 26619823 Free PMC article.
Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice.
Suzuki-Kemuriyama N, Matsuzaka T, Kuba M, Ohno H, Han SI, Takeuchi Y, Isaka M, Kobayashi K, Iwasaki H, Yatoh S, Suzuki H, Miyajima K, Nakae D, Yahagi N, Nakagawa Y, Sone H, Yamada N, Shimano H. Suzuki-Kemuriyama N, et al. Among authors: kobayashi k. PLoS One. 2016 Jun 22;11(6):e0157580. doi: 10.1371/journal.pone.0157580. eCollection 2016. PLoS One. 2016. PMID: 27333187 Free PMC article.
Mouse Elovl-6 promoter is an SREBP target.
Kumadaki S, Matsuzaka T, Kato T, Yahagi N, Yamamoto T, Okada S, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Yamada N, Shimano H. Kumadaki S, et al. Among authors: kobayashi k. Biochem Biophys Res Commun. 2008 Apr 4;368(2):261-6. doi: 10.1016/j.bbrc.2008.01.075. Epub 2008 Jan 28. Biochem Biophys Res Commun. 2008. PMID: 18226595
Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance.
Inoue N, Yahagi N, Yamamoto T, Ishikawa M, Watanabe K, Matsuzaka T, Nakagawa Y, Takeuchi Y, Kobayashi K, Takahashi A, Suzuki H, Hasty AH, Toyoshima H, Yamada N, Shimano H. Inoue N, et al. Among authors: kobayashi k. J Biol Chem. 2008 Jul 25;283(30):21220-9. doi: 10.1074/jbc.M801824200. Epub 2008 Apr 29. J Biol Chem. 2008. PMID: 18445590 Free PMC article.
Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets.
Kato T, Shimano H, Yamamoto T, Ishikawa M, Kumadaki S, Matsuzaka T, Nakagawa Y, Yahagi N, Nakakuki M, Hasty AH, Takeuchi Y, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Sone H, Yamada N. Kato T, et al. Among authors: kobayashi k. Diabetes. 2008 Sep;57(9):2382-92. doi: 10.2337/db06-1806. Epub 2008 May 5. Diabetes. 2008. PMID: 18458149 Free PMC article.
Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity.
Ishikawa M, Iwasaki Y, Yatoh S, Kato T, Kumadaki S, Inoue N, Yamamoto T, Matsuzaka T, Nakagawa Y, Yahagi N, Kobayashi K, Takahashi A, Yamada N, Shimano H. Ishikawa M, et al. Among authors: kobayashi k. J Lipid Res. 2008 Dec;49(12):2524-34. doi: 10.1194/jlr.M800238-JLR200. Epub 2008 Aug 5. J Lipid Res. 2008. PMID: 18682608 Free article.
Nuclear SREBP-1a causes loss of pancreatic beta-cells and impaired insulin secretion.
Iwasaki Y, Iwasaki H, Yatoh S, Ishikawa M, Kato T, Matsuzaka T, Nakagawa Y, Yahagi N, Kobayashi K, Takahashi A, Suzuki H, Yamada N, Shimano H. Iwasaki Y, et al. Among authors: kobayashi k. Biochem Biophys Res Commun. 2009 Jan 16;378(3):545-50. doi: 10.1016/j.bbrc.2008.11.105. Epub 2008 Dec 3. Biochem Biophys Res Commun. 2009. PMID: 19056350
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