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A first-in-human phase 0 clinical study of RNA interference-based spherical nucleic acids in patients with recurrent glioblastoma.
Kumthekar P, Ko CH, Paunesku T, Dixit K, Sonabend AM, Bloch O, Tate M, Schwartz M, Zuckerman L, Lezon R, Lukas RV, Jovanovic B, McCortney K, Colman H, Chen S, Lai B, Antipova O, Deng J, Li L, Tommasini-Ghelfi S, Hurley LA, Unruh D, Sharma NV, Kandpal M, Kouri FM, Davuluri RV, Brat DJ, Muzzio M, Glass M, Vijayakumar V, Heidel J, Giles FJ, Adams AK, James CD, Woloschak GE, Horbinski C, Stegh AH. Kumthekar P, et al. Among authors: ko ch. Sci Transl Med. 2021 Mar 10;13(584):eabb3945. doi: 10.1126/scitranslmed.abb3945. Sci Transl Med. 2021. PMID: 33692132 Free PMC article. Clinical Trial.
Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma.
Jensen SA, Day ES, Ko CH, Hurley LA, Luciano JP, Kouri FM, Merkel TJ, Luthi AJ, Patel PC, Cutler JI, Daniel WL, Scott AW, Rotz MW, Meade TJ, Giljohann DA, Mirkin CA, Stegh AH. Jensen SA, et al. Among authors: ko ch. Sci Transl Med. 2013 Oct 30;5(209):209ra152. doi: 10.1126/scitranslmed.3006839. Sci Transl Med. 2013. PMID: 24174328 Free PMC article.
Nanotechnology for synthetic high-density lipoproteins.
Luthi AJ, Patel PC, Ko CH, Mutharasan RK, Mirkin CA, Thaxton CS. Luthi AJ, et al. Among authors: ko ch. Trends Mol Med. 2010 Dec;16(12):553-60. doi: 10.1016/j.molmed.2010.10.006. Epub 2010 Nov 17. Trends Mol Med. 2010. PMID: 21087901 Free PMC article.
535 results