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A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins.
Lu X, Chandravanshi M, Sabbasani VR, Gaikwad S, Hughitt VK, Gyabaah-Kessie N, Scroggins BT, Das S, Myint W, Clapp ME, Schwieters CD, Dyba MA, Bolhuis DL, Koscielniak JW, Andresson T, Emanuele MJ, Brown NG, Matsuo H, Chari R, Citrin DE, Mock BA, Swenson RE, Walters KJ. Lu X, et al. Among authors: koscielniak jw. Nat Commun. 2024 Mar 20;15(1):2485. doi: 10.1038/s41467-024-46644-7. Nat Commun. 2024. PMID: 38509117 Free PMC article.
Two Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease.
Bateman RJ, Smith J, Donohue MC, Delmar P, Abbas R, Salloway S, Wojtowicz J, Blennow K, Bittner T, Black SE, Klein G, Boada M, Grimmer T, Tamaoka A, Perry RJ, Turner RS, Watson D, Woodward M, Thanasopoulou A, Lane C, Baudler M, Fox NC, Cummings JL, Fontoura P, Doody RS; GRADUATE I and II Investigators and the Gantenerumab Study Group. Bateman RJ, et al. N Engl J Med. 2023 Nov 16;389(20):1862-1876. doi: 10.1056/NEJMoa2304430. N Engl J Med. 2023. PMID: 37966285 Clinical Trial.
Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial.
Cree BAC, Cutter G, Wolinsky JS, Freedman MS, Comi G, Giovannoni G, Hartung HP, Arnold D, Kuhle J, Block V, Munschauer FE, Sedel F, Lublin FD; SPI2 investigative teams. Cree BAC, et al. Lancet Neurol. 2020 Dec;19(12):988-997. doi: 10.1016/S1474-4422(20)30347-1. Epub 2020 Oct 23. Lancet Neurol. 2020. PMID: 33222767 Clinical Trial.
The role of chloroplasts in the oxidative stress that is induced by zearalenone in wheat plants - The functions of 24-epibrassinolide and selenium in the protective mechanisms.
Filek M, Sieprawska A, Kościelniak J, Oklestkova J, Jurczyk B, Telk A, Biesaga-Kościelniak J, Janeczko A. Filek M, et al. Among authors: koscielniak j. Plant Physiol Biochem. 2019 Apr;137:84-92. doi: 10.1016/j.plaphy.2019.01.030. Epub 2019 Feb 1. Plant Physiol Biochem. 2019. PMID: 30769236
Prioritization of Candidate Genes in QTL Regions for Physiological and Biochemical Traits Underlying Drought Response in Barley (Hordeum vulgare L.).
Gudys K, Guzy-Wrobelska J, Janiak A, Dziurka MA, Ostrowska A, Hura K, Jurczyk B, Żmuda K, Grzybkowska D, Śróbka J, Urban W, Biesaga-Koscielniak J, Filek M, Koscielniak J, Mikołajczak K, Ogrodowicz P, Krystkowiak K, Kuczyńska A, Krajewski P, Szarejko I. Gudys K, et al. Among authors: koscielniak j. Front Plant Sci. 2018 Jun 12;9:769. doi: 10.3389/fpls.2018.00769. eCollection 2018. Front Plant Sci. 2018. PMID: 29946328 Free PMC article.
The relationship between pulse waveform analysis indices, endothelial function and clinical outcomes in patients with peripheral artery disease treated using percutaneous transluminal angioplasty during a one-year follow-up period.
Kaczmarczyk P, Maga P, Niżankowski R, Januszek R, Frołow M, Maga M, Kościelniak J, Belowski A. Kaczmarczyk P, et al. Among authors: koscielniak j. Cardiol J. 2020;27(2):142-151. doi: 10.5603/CJ.a2018.0026. Epub 2018 Apr 3. Cardiol J. 2020. PMID: 29611173 Free PMC article.
33 results