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GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion.
Gandasi NR, Gao R, Kothegala L, Pearce A, Santos C, Acreman S, Basco D, Benrick A, Chibalina MV, Clark A, Guida C, Harris M, Johnson PRV, Knudsen JG, Ma J, Miranda C, Shigeto M, Tarasov AI, Yeung HY, Thorens B, Asterholm IW, Zhang Q, Ramracheya R, Ladds G, Rorsman P. Gandasi NR, et al. Among authors: knudsen jg. Diabetologia. 2024 Mar;67(3):528-546. doi: 10.1007/s00125-023-06060-w. Epub 2023 Dec 21. Diabetologia. 2024. PMID: 38127123 Free PMC article.
Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells.
Hamilton A, Zhang Q, Salehi A, Willems M, Knudsen JG, Ringgaard AK, Chapman CE, Gonzalez-Alvarez A, Surdo NC, Zaccolo M, Basco D, Johnson PRV, Ramracheya R, Rutter GA, Galione A, Rorsman P, Tarasov AI. Hamilton A, et al. Among authors: knudsen jg. Diabetes. 2018 Jun;67(6):1128-1139. doi: 10.2337/db17-1102. Epub 2018 Mar 21. Diabetes. 2018. PMID: 29563152 Free PMC article.
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.
Vergari E, Knudsen JG, Ramracheya R, Salehi A, Zhang Q, Adam J, Asterholm IW, Benrick A, Briant LJB, Chibalina MV, Gribble FM, Hamilton A, Hastoy B, Reimann F, Rorsman NJG, Spiliotis II, Tarasov A, Wu Y, Ashcroft FM, Rorsman P. Vergari E, et al. Among authors: knudsen jg. Nat Commun. 2019 Jan 11;10(1):139. doi: 10.1038/s41467-018-08193-8. Nat Commun. 2019. PMID: 30635569 Free PMC article.
Loss of tetraspanin-7 expression reduces pancreatic β-cell exocytosis Ca2+ sensitivity but has limited effect on systemic metabolism.
McLaughlin K, Acreman S, Nawaz S, Cutteridge J, Clark A, Knudsen JG, Denwood G, Spigelman AF, Manning Fox JE, Singh SP, MacDonald PE, Hastoy B, Zhang Q. McLaughlin K, et al. Among authors: knudsen jg. Diabet Med. 2022 Dec;39(12):e14984. doi: 10.1111/dme.14984. Epub 2022 Oct 31. Diabet Med. 2022. PMID: 36264270 Free PMC article.
Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes.
Kim A, Knudsen JG, Madara JC, Benrick A, Hill TG, Abdul Kadir L, Kellard JA, Mellander L, Miranda C, Lin H, James T, Suba K, Spigelman AF, Wu Y, MacDonald PE, Wernstedt Asterholm I, Magnussen T, Christensen M, Vilsbøll T, Salem V, Knop FK, Rorsman P, Lowell BB, Briant LJ. Kim A, et al. Among authors: knudsen jg. Elife. 2021 Nov 17;10:e72919. doi: 10.7554/eLife.72919. Elife. 2021. PMID: 34787082 Free PMC article.
28 results