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Short chain fatty acids: Microbial metabolites for gut-brain axis signalling.
O'Riordan KJ, Collins MK, Moloney GM, Knox EG, Aburto MR, Fülling C, Morley SJ, Clarke G, Schellekens H, Cryan JF. O'Riordan KJ, et al. Among authors: knox eg. Mol Cell Endocrinol. 2022 Apr 15;546:111572. doi: 10.1016/j.mce.2022.111572. Epub 2022 Jan 20. Mol Cell Endocrinol. 2022. PMID: 35066114 Free article. Review.
The blood-brain barrier in aging and neurodegeneration.
Knox EG, Aburto MR, Clarke G, Cryan JF, O'Driscoll CM. Knox EG, et al. Mol Psychiatry. 2022 Jun;27(6):2659-2673. doi: 10.1038/s41380-022-01511-z. Epub 2022 Mar 31. Mol Psychiatry. 2022. PMID: 35361905 Free PMC article. Review.
Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington's disease models.
Conroy F, Miller R, Alterman JF, Hassler MR, Echeverria D, Godinho BMDC, Knox EG, Sapp E, Sousa J, Yamada K, Mahmood F, Boudi A, Kegel-Gleason K, DiFiglia M, Aronin N, Khvorova A, Pfister EL. Conroy F, et al. Among authors: knox eg. Nat Commun. 2022 Oct 3;13(1):5802. doi: 10.1038/s41467-022-33061-x. Nat Commun. 2022. PMID: 36192390 Free PMC article.
PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs.
Godinho BMDC, Knox EG, Hildebrand S, Gilbert JW, Echeverria D, Kennedy Z, Haraszti RA, Ferguson CM, Coles AH, Biscans A, Caiazzi J, Alterman JF, Hassler MR, Khvorova A. Godinho BMDC, et al. Among authors: knox eg. Mol Ther Nucleic Acids. 2022 Jun 13;29:116-132. doi: 10.1016/j.omtn.2022.06.005. eCollection 2022 Sep 13. Mol Ther Nucleic Acids. 2022. PMID: 35795486 Free PMC article.
Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep.
Ferguson CM, Godinho BM, Alterman JF, Coles AH, Hassler M, Echeverria D, Gilbert JW, Knox EG, Caiazzi J, Haraszti RA, King RM, Taghian T, Puri A, Moser RP, Gounis MJ, Aronin N, Gray-Edwards H, Khvorova A. Ferguson CM, et al. Among authors: knox eg. JCI Insight. 2021 Dec 22;6(24):e152203. doi: 10.1172/jci.insight.152203. JCI Insight. 2021. PMID: 34935646 Free PMC article.
A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system.
Alterman JF, Godinho BMDC, Hassler MR, Ferguson CM, Echeverria D, Sapp E, Haraszti RA, Coles AH, Conroy F, Miller R, Roux L, Yan P, Knox EG, Turanov AA, King RM, Gernoux G, Mueller C, Gray-Edwards HL, Moser RP, Bishop NC, Jaber SM, Gounis MJ, Sena-Esteves M, Pai AA, DiFiglia M, Aronin N, Khvorova A. Alterman JF, et al. Among authors: knox eg. Nat Biotechnol. 2019 Aug;37(8):884-894. doi: 10.1038/s41587-019-0205-0. Epub 2019 Aug 2. Nat Biotechnol. 2019. PMID: 31375812 Free PMC article.
Implementation of a system-wide policy for labor induction.
O'Rourke TP, Girardi GJ, Balaskas TN, Havlisch RA, Landstrom G, Kirby B, Knox EG, Simpson KR. O'Rourke TP, et al. Among authors: knox eg. MCN Am J Matern Child Nurs. 2011 Sep-Oct;36(5):305-11. doi: 10.1097/NMC.0b013e3182069e12. MCN Am J Matern Child Nurs. 2011. PMID: 21857201
115 results