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Modest reductions of cardiac calsequestrin increase sarcoplasmic reticulum Ca2+ leak independent of luminal Ca2+ and trigger ventricular arrhythmias in mice.
Chopra N, Kannankeril PJ, Yang T, Hlaing T, Holinstat I, Ettensohn K, Pfeifer K, Akin B, Jones LR, Franzini-Armstrong C, Knollmann BC. Chopra N, et al. Among authors: knollmann bc. Circ Res. 2007 Sep 14;101(6):617-26. doi: 10.1161/CIRCRESAHA.107.157552. Epub 2007 Jul 26. Circ Res. 2007. PMID: 17656677
Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia.
Hwang HS, Hasdemir C, Laver D, Mehra D, Turhan K, Faggioni M, Yin H, Knollmann BC. Hwang HS, et al. Among authors: knollmann bc. Circ Arrhythm Electrophysiol. 2011 Apr;4(2):128-35. doi: 10.1161/CIRCEP.110.959916. Epub 2011 Jan 26. Circ Arrhythm Electrophysiol. 2011. PMID: 21270101 Free PMC article.
Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro.
Watanabe H, Yang T, Stroud DM, Lowe JS, Harris L, Atack TC, Wang DW, Hipkens SB, Leake B, Hall L, Kupershmidt S, Chopra N, Magnuson MA, Tanabe N, Knollmann BC, George AL Jr, Roden DM. Watanabe H, et al. Among authors: knollmann bc. Circulation. 2011 Aug 30;124(9):1001-11. doi: 10.1161/CIRCULATIONAHA.110.987248. Epub 2011 Aug 8. Circulation. 2011. PMID: 21824921 Free PMC article.
Calsequestrin 2 and arrhythmias.
Faggioni M, Knollmann BC. Faggioni M, et al. Among authors: knollmann bc. Am J Physiol Heart Circ Physiol. 2012 Mar 15;302(6):H1250-60. doi: 10.1152/ajpheart.00779.2011. Epub 2011 Dec 23. Am J Physiol Heart Circ Physiol. 2012. PMID: 22198169 Free PMC article. Review.
179 results