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First-in-Class Dual Mechanism Ferroptosis-HDAC Inhibitor Hybrids.
J Med Chem. 2022 Nov 10;65(21):14764-14791. doi: 10.1021/acs.jmedchem.2c01276. Epub 2022 Oct 28.
J Med Chem. 2022.
PMID: 36306372
Free PMC article.
A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics.
Al-Hamashi AA, Koranne R, Dlamini S, Alqahtani A, Karaj E, Rashid MS, Knoff JR, Dunworth M, Pflum MKH, Casero RA Jr, Perera L, Taylor WR, Tillekeratne LMV.
Al-Hamashi AA, et al. Among authors: knoff jr.
Bioorg Chem. 2021 Nov;116:105297. doi: 10.1016/j.bioorg.2021.105297. Epub 2021 Aug 30.
Bioorg Chem. 2021.
PMID: 34509798
Free PMC article.
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The structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity.
Negmeldin AT, Knoff JR, Pflum MKH.
Negmeldin AT, et al. Among authors: knoff jr.
Eur J Med Chem. 2018 Jan 1;143:1790-1806. doi: 10.1016/j.ejmech.2017.10.076. Epub 2017 Oct 31.
Eur J Med Chem. 2018.
PMID: 29150330
Free PMC article.
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