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Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions.
Schwabenland M, Salié H, Tanevski J, Killmer S, Lago MS, Schlaak AE, Mayer L, Matschke J, Püschel K, Fitzek A, Ondruschka B, Mei HE, Boettler T, Neumann-Haefelin C, Hofmann M, Breithaupt A, Genc N, Stadelmann C, Saez-Rodriguez J, Bronsert P, Knobeloch KP, Blank T, Thimme R, Glatzel M, Prinz M, Bengsch B. Schwabenland M, et al. Among authors: knobeloch kp. Immunity. 2021 Jul 13;54(7):1594-1610.e11. doi: 10.1016/j.immuni.2021.06.002. Epub 2021 Jun 9. Immunity. 2021. PMID: 34174183 Free PMC article.
IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system.
Raasch J, Zeller N, van Loo G, Merkler D, Mildner A, Erny D, Knobeloch KP, Bethea JR, Waisman A, Knust M, Del Turco D, Deller T, Blank T, Priller J, Brück W, Pasparakis M, Prinz M. Raasch J, et al. Among authors: knobeloch kp. Brain. 2011 Apr;134(Pt 4):1184-98. doi: 10.1093/brain/awq359. Epub 2011 Feb 10. Brain. 2011. PMID: 21310728 Free PMC article.
mHERC6 is the essential ISG15 E3 ligase in the murine system.
Ketscher L, Basters A, Prinz M, Knobeloch KP. Ketscher L, et al. Among authors: knobeloch kp. Biochem Biophys Res Commun. 2012 Jan 6;417(1):135-40. doi: 10.1016/j.bbrc.2011.11.071. Epub 2011 Nov 23. Biochem Biophys Res Commun. 2012. PMID: 22138649
Genetic targeting of microglia.
Wieghofer P, Knobeloch KP, Prinz M. Wieghofer P, et al. Among authors: knobeloch kp. Glia. 2015 Jan;63(1):1-22. doi: 10.1002/glia.22727. Epub 2014 Aug 8. Glia. 2015. PMID: 25132502 Review.
USP18 lack in microglia causes destructive interferonopathy of the mouse brain.
Goldmann T, Zeller N, Raasch J, Kierdorf K, Frenzel K, Ketscher L, Basters A, Staszewski O, Brendecke SM, Spiess A, Tay TL, Kreutz C, Timmer J, Mancini GM, Blank T, Fritz G, Biber K, Lang R, Malo D, Merkler D, Heikenwälder M, Knobeloch KP, Prinz M. Goldmann T, et al. Among authors: knobeloch kp. EMBO J. 2015 Jun 12;34(12):1612-29. doi: 10.15252/embj.201490791. Epub 2015 Apr 20. EMBO J. 2015. PMID: 25896511 Free PMC article.
Loss of USP18 in microglia induces white matter pathology.
Schwabenland M, Mossad O, Peres AG, Kessler F, Maron FJM, Harsan LA, Bienert T, von Elverfeldt D, Knobeloch KP, Staszewski O, Heppner FL, Meuwissen MEC, Mancini GMS, Prinz M, Blank T. Schwabenland M, et al. Among authors: knobeloch kp. Acta Neuropathol Commun. 2019 Jul 4;7(1):106. doi: 10.1186/s40478-019-0757-8. Acta Neuropathol Commun. 2019. PMID: 31272490 Free PMC article. No abstract available.
Novel Hexb-based tools for studying microglia in the CNS.
Masuda T, Amann L, Sankowski R, Staszewski O, Lenz M, D Errico P, Snaidero N, Costa Jordão MJ, Böttcher C, Kierdorf K, Jung S, Priller J, Misgeld T, Vlachos A, Meyer-Luehmann M, Knobeloch KP, Prinz M. Masuda T, et al. Among authors: knobeloch kp. Nat Immunol. 2020 Jul;21(7):802-815. doi: 10.1038/s41590-020-0707-4. Epub 2020 Jun 15. Nat Immunol. 2020. PMID: 32541832
89 results