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IL-6 promotes immune responses in human ulcerative colitis and induces a skin-homing phenotype in the dendritic cells and Tcells they stimulate.
Bernardo D, Vallejo-Díez S, Mann ER, Al-Hassi HO, Martínez-Abad B, Montalvillo E, Tee CT, Murugananthan AU, Núñez H, Peake ST, Hart AL, Fernández-Salazar L, Garrote JA, Arranz E, Knight SC. Bernardo D, et al. Among authors: knight sc. Eur J Immunol. 2012 May;42(5):1337-53. doi: 10.1002/eji.201142327. Eur J Immunol. 2012. PMID: 22539302 Free article.
Altered human gut dendritic cell properties in ulcerative colitis are reversed by Lactobacillus plantarum extracellular encrypted peptide STp.
Al-Hassi HO, Mann ER, Sanchez B, English NR, Peake ST, Landy J, Man R, Urdaci M, Hart AL, Fernandez-Salazar L, Lee GH, Garrote JA, Arranz E, Margolles A, Stagg AJ, Knight SC, Bernardo D. Al-Hassi HO, et al. Among authors: knight sc. Mol Nutr Food Res. 2014 May;58(5):1132-43. doi: 10.1002/mnfr.201300596. Epub 2013 Dec 18. Mol Nutr Food Res. 2014. PMID: 24347371 Free article.
Human gut dendritic cells drive aberrant gut-specific t-cell responses in ulcerative colitis, characterized by increased IL-4 production and loss of IL-22 and IFNγ.
Mann ER, Bernardo D, Ng SC, Rigby RJ, Al-Hassi HO, Landy J, Peake ST, Spranger H, English NR, Thomas LV, Stagg AJ, Knight SC, Hart AL. Mann ER, et al. Among authors: knight sc. Inflamm Bowel Dis. 2014 Dec;20(12):2299-307. doi: 10.1097/MIB.0000000000000223. Inflamm Bowel Dis. 2014. PMID: 25397892
252 results