Knapp S - Search Results

1

[b]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors.

Lechner C, Flaßhoff M, Falke H, Preu L, Loaëc N, Meijer L, Knapp S, Chaikuad A, Kunick C. Lechner C, et al. Among authors: knapp s. Molecules. 2019 Nov 13;24(22):4090. doi: 10.3390/molecules24224090. Molecules. 2019. PMID: 31766108 Free PMC article.

2

Structural comparison of human mammalian ste20-like kinases.

Record CJ, Chaikuad A, Rellos P, Das S, Pike AC, Fedorov O, Marsden BD, Knapp S, Lee WH. Record CJ, et al. Among authors: knapp s. PLoS One. 2010 Aug 6;5(8):e11905. doi: 10.1371/journal.pone.0011905. PLoS One. 2010. PMID: 20730082 Free PMC article.

3

Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

Debdab M, Carreaux F, Renault S, Soundararajan M, Fedorov O, Filippakopoulos P, Lozach O, Babault L, Tahtouh T, Baratte B, Ogawa Y, Hagiwara M, Eisenreich A, Rauch U, Knapp S, Meijer L, Bazureau JP. Debdab M, et al. Among authors: knapp s. J Med Chem. 2011 Jun 23;54(12):4172-86. doi: 10.1021/jm200274d. Epub 2011 May 26. J Med Chem. 2011. PMID: 21615147

4

Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.

Tahtouh T, Elkins JM, Filippakopoulos P, Soundararajan M, Burgy G, Durieu E, Cochet C, Schmid RS, Lo DC, Delhommel F, Oberholzer AE, Pearl LH, Carreaux F, Bazureau JP, Knapp S, Meijer L. Tahtouh T, et al. Among authors: knapp s. J Med Chem. 2012 Nov 8;55(21):9312-30. doi: 10.1021/jm301034u. Epub 2012 Oct 8. J Med Chem. 2012. PMID: 22998443

5

Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain.

Ferguson FM, Fedorov O, Chaikuad A, Philpott M, Muniz JR, Felletar I, von Delft F, Heightman T, Knapp S, Abell C, Ciulli A. Ferguson FM, et al. Among authors: knapp s. J Med Chem. 2013 Dec 27;56(24):10183-7. doi: 10.1021/jm401582c. Epub 2013 Dec 13. J Med Chem. 2013. PMID: 24304323 Free PMC article.

6

Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.

Chaikuad A, Keates T, Vincke C, Kaufholz M, Zenn M, Zimmermann B, Gutiérrez C, Zhang RG, Hatzos-Skintges C, Joachimiak A, Muyldermans S, Herberg FW, Knapp S, Müller S. Chaikuad A, et al. Among authors: knapp s. Biochem J. 2014 Apr 1;459(1):59-69. doi: 10.1042/BJ20131399. Biochem J. 2014. PMID: 24438162 Free PMC article.

7

Modulation of the chromatin phosphoproteome by the Haspin protein kinase.

Maiolica A, de Medina-Redondo M, Schoof EM, Chaikuad A, Villa F, Gatti M, Jeganathan S, Lou HJ, Novy K, Hauri S, Toprak UH, Herzog F, Meraldi P, Penengo L, Turk BE, Knapp S, Linding R, Aebersold R. Maiolica A, et al. Among authors: knapp s. Mol Cell Proteomics. 2014 Jul;13(7):1724-40. doi: 10.1074/mcp.M113.034819. Epub 2014 Apr 14. Mol Cell Proteomics. 2014. PMID: 24732914 Free PMC article.

8

A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics.

Chaikuad A, Tacconi EM, Zimmer J, Liang Y, Gray NS, Tarsounas M, Knapp S. Chaikuad A, et al. Among authors: knapp s. Nat Chem Biol. 2014 Oct;10(10):853-60. doi: 10.1038/nchembio.1629. Epub 2014 Sep 7. Nat Chem Biol. 2014. PMID: 25195011 Free PMC article.

9

Bisubstrate inhibitor approach for targeting mitotic kinase Haspin.

Kestav K, Lavogina D, Raidaru G, Chaikuad A, Knapp S, Uri A. Kestav K, et al. Among authors: knapp s. Bioconjug Chem. 2015 Feb 18;26(2):225-34. doi: 10.1021/bc500464r. Epub 2015 Jan 29. Bioconjug Chem. 2015. PMID: 25595038

10

Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B.

Drouin L, McGrath S, Vidler LR, Chaikuad A, Monteiro O, Tallant C, Philpott M, Rogers C, Fedorov O, Liu M, Akhtar W, Hayes A, Raynaud F, Müller S, Knapp S, Hoelder S. Drouin L, et al. Among authors: knapp s. J Med Chem. 2015 Mar 12;58(5):2553-9. doi: 10.1021/jm501963e. Epub 2015 Feb 26. J Med Chem. 2015. PMID: 25719566 Free PMC article.

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