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Page 1
Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants.
Zhang W, Bailey-Elkin BA, Knaap RCM, Khare B, Dalebout TJ, Johnson GG, van Kasteren PB, McLeish NJ, Gu J, He W, Kikkert M, Mark BL, Sidhu SS. Zhang W, et al. Among authors: knaap rcm. PLoS Pathog. 2017 May 18;13(5):e1006372. doi: 10.1371/journal.ppat.1006372. eCollection 2017 May. PLoS Pathog. 2017. PMID: 28542609 Free PMC article.
Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression.
Bailey-Elkin BA, Knaap RC, Johnson GG, Dalebout TJ, Ninaber DK, van Kasteren PB, Bredenbeek PJ, Snijder EJ, Kikkert M, Mark BL. Bailey-Elkin BA, et al. J Biol Chem. 2014 Dec 12;289(50):34667-82. doi: 10.1074/jbc.M114.609644. Epub 2014 Oct 15. J Biol Chem. 2014. PMID: 25320088 Free PMC article.
Structure and Function of Viral Deubiquitinating Enzymes.
Bailey-Elkin BA, Knaap RCM, Kikkert M, Mark BL. Bailey-Elkin BA, et al. Among authors: knaap rcm. J Mol Biol. 2017 Nov 10;429(22):3441-3470. doi: 10.1016/j.jmb.2017.06.010. Epub 2017 Jun 16. J Mol Biol. 2017. PMID: 28625850 Free PMC article. Review.
Profiling DUBs and Ubl-specific proteases with activity-based probes.
Geurink PP, van der Heden van Noort GJ, Mulder MPC, Knaap RCM, Kikkert M, Ovaa H. Geurink PP, et al. Among authors: knaap rcm. Methods Enzymol. 2019;618:357-387. doi: 10.1016/bs.mie.2018.12.037. Epub 2019 Feb 14. Methods Enzymol. 2019. PMID: 30850060 Free PMC article.
Engineering potent live attenuated coronavirus vaccines by targeted inactivation of the immune evasive viral deubiquitinase.
Myeni SK, Bredenbeek PJ, Knaap RCM, Dalebout TJ, Morales ST, Sidorov IA, Linger ME, Oreshkova N, van Zanen-Gerhardt S, Zander SAL, Enjuanes L, Sola I, Snijder EJ, Kikkert M. Myeni SK, et al. Among authors: knaap rcm. Nat Commun. 2023 Feb 28;14(1):1141. doi: 10.1038/s41467-023-36754-z. Nat Commun. 2023. PMID: 36854765 Free PMC article.
Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis.
Bailey-Elkin BA, Knaap RCM, De Silva A, Boekhoud IM, Mous S, van Vught N, Khajehpour M, van den Born E, Kikkert M, Mark BL. Bailey-Elkin BA, et al. Among authors: knaap rcm. PLoS Pathog. 2023 Dec 14;19(12):e1011872. doi: 10.1371/journal.ppat.1011872. eCollection 2023 Dec. PLoS Pathog. 2023. PMID: 38096325 Free PMC article.
Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivo.
van Huizen M, Bloeme-Ter Horst JR, de Gruyter HLM, Geurink PP, van der Heden van Noort GJ, Knaap RCM, Nelemans T, Ogando NS, Leijs AA, Urakova N, Mark BL, Snijder EJ, Myeni SK, Kikkert M. van Huizen M, et al. Among authors: knaap rcm. PLoS Pathog. 2024 Mar 25;20(3):e1012100. doi: 10.1371/journal.ppat.1012100. eCollection 2024 Mar. PLoS Pathog. 2024. PMID: 38527094 Free PMC article.