Kluck RM - Search Results

1

Ensemble Properties of Bax Determine Its Function.

Robin AY, Iyer S, Birkinshaw RW, Sandow J, Wardak A, Luo CS, Shi M, Webb AI, Czabotar PE, Kluck RM, Colman PM. Robin AY, et al. Among authors: kluck rm. Structure. 2018 Oct 2;26(10):1346-1359.e5. doi: 10.1016/j.str.2018.07.006. Epub 2018 Aug 16. Structure. 2018. PMID: 30122452 Free article.

2

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DC. Willis SN, et al. Among authors: kluck rm. Science. 2007 Feb 9;315(5813):856-9. doi: 10.1126/science.1133289. Science. 2007. PMID: 17289999

3

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

Dewson G, Kratina T, Sim HW, Puthalakath H, Adams JM, Colman PM, Kluck RM. Dewson G, et al. Among authors: kluck rm. Mol Cell. 2008 May 9;30(3):369-80. doi: 10.1016/j.molcel.2008.04.005. Mol Cell. 2008. PMID: 18471982 Free article.

4

Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis.

Dewson G, Kluck RM. Dewson G, et al. Among authors: kluck rm. J Cell Sci. 2009 Aug 15;122(Pt 16):2801-8. doi: 10.1242/jcs.038166. J Cell Sci. 2009. PMID: 19795525 Free PMC article.

5

Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices.

Dewson G, Kratina T, Czabotar P, Day CL, Adams JM, Kluck RM. Dewson G, et al. Among authors: kluck rm. Mol Cell. 2009 Nov 25;36(4):696-703. doi: 10.1016/j.molcel.2009.11.008. Mol Cell. 2009. PMID: 19941828 Free article.

6

Molecular biology of Bax and Bak activation and action.

Westphal D, Dewson G, Czabotar PE, Kluck RM. Westphal D, et al. Among authors: kluck rm. Biochim Biophys Acta. 2011 Apr;1813(4):521-31. doi: 10.1016/j.bbamcr.2010.12.019. Epub 2010 Dec 30. Biochim Biophys Acta. 2011. PMID: 21195116 Free article. Review.

7

Bax dimerizes via a symmetric BH3:groove interface during apoptosis.

Dewson G, Ma S, Frederick P, Hockings C, Tan I, Kratina T, Kluck RM. Dewson G, et al. Among authors: kluck rm. Cell Death Differ. 2012 Apr;19(4):661-70. doi: 10.1038/cdd.2011.138. Epub 2011 Oct 21. Cell Death Differ. 2012. PMID: 22015607 Free PMC article.

8

Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function.

Ferrer PE, Frederick P, Gulbis JM, Dewson G, Kluck RM. Ferrer PE, et al. Among authors: kluck rm. PLoS One. 2012;7(3):e31510. doi: 10.1371/journal.pone.0031510. Epub 2012 Mar 19. PLoS One. 2012. PMID: 22442658 Free PMC article.

9

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.

Czabotar PE, Westphal D, Dewson G, Ma S, Hockings C, Fairlie WD, Lee EF, Yao S, Robin AY, Smith BJ, Huang DC, Kluck RM, Adams JM, Colman PM. Czabotar PE, et al. Among authors: kluck rm. Cell. 2013 Jan 31;152(3):519-31. doi: 10.1016/j.cell.2012.12.031. Cell. 2013. PMID: 23374347 Free article.

10

Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis.

Westphal D, Kluck RM, Dewson G. Westphal D, et al. Among authors: kluck rm. Cell Death Differ. 2014 Feb;21(2):196-205. doi: 10.1038/cdd.2013.139. Epub 2013 Oct 25. Cell Death Differ. 2014. PMID: 24162660 Free PMC article. Review.

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