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Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.
Weaver RJ, Blomme EA, Chadwick AE, Copple IM, Gerets HHJ, Goldring CE, Guillouzo A, Hewitt PG, Ingelman-Sundberg M, Jensen KG, Juhila S, Klingmüller U, Labbe G, Liguori MJ, Lovatt CA, Morgan P, Naisbitt DJ, Pieters RHH, Snoeys J, van de Water B, Williams DP, Park BK. Weaver RJ, et al. Among authors: klingmuller u. Nat Rev Drug Discov. 2020 Feb;19(2):131-148. doi: 10.1038/s41573-019-0048-x. Epub 2019 Nov 20. Nat Rev Drug Discov. 2020. PMID: 31748707 Free article. Review.
Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds.
Oppelt A, Kaschek D, Huppelschoten S, Sison-Young R, Zhang F, Buck-Wiese M, Herrmann F, Malkusch S, Krüger CL, Meub M, Merkt B, Zimmermann L, Schofield A, Jones RP, Malik H, Schilling M, Heilemann M, van de Water B, Goldring CE, Park BK, Timmer J, Klingmüller U. Oppelt A, et al. Among authors: klingmuller u. NPJ Syst Biol Appl. 2018 Jun 11;4:23. doi: 10.1038/s41540-018-0058-z. eCollection 2018. NPJ Syst Biol Appl. 2018. PMID: 29900006 Free PMC article.
The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro.
Giustarini G, Huppelschoten S, Barra M, Oppelt A, Wagenaar L, Weaver RJ, Bol-Schoenmakers M, Smit JJ, van de Water B, Klingmüller U, Pieters RHH. Giustarini G, et al. Among authors: klingmuller u. Toxicol Appl Pharmacol. 2020 Mar 15;391:114915. doi: 10.1016/j.taap.2020.114915. Epub 2020 Feb 6. Toxicol Appl Pharmacol. 2020. PMID: 32035082
Predictive mathematical models of cancer signalling pathways.
Bachmann J, Raue A, Schilling M, Becker V, Timmer J, Klingmüller U. Bachmann J, et al. Among authors: klingmuller u. J Intern Med. 2012 Feb;271(2):155-65. doi: 10.1111/j.1365-2796.2011.02492.x. J Intern Med. 2012. PMID: 22142263 Free article. Review.
Predicting liver regeneration following major resection.
Dehlke K, Krause L, Tyufekchieva S, Murtha-Lemekhova A, Mayer P, Vlasov A, Klingmüller U, Mueller NS, Hoffmann K. Dehlke K, et al. Among authors: klingmuller u. Sci Rep. 2022 Aug 4;12(1):13396. doi: 10.1038/s41598-022-16968-9. Sci Rep. 2022. PMID: 35927556 Free PMC article.
Hepatocellular carcinoma: a systems biology perspective.
D'Alessandro LA, Meyer R, Klingmüller U. D'Alessandro LA, et al. Among authors: klingmuller u. Front Physiol. 2013 Feb 25;4:28. doi: 10.3389/fphys.2013.00028. eCollection 2013. Front Physiol. 2013. PMID: 23444340 Free PMC article.
133 results