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A randomized, double-blind, placebo-controlled, dose-escalating phase I trial to evaluate safety and immunogenicity of a plant-produced, bivalent, recombinant norovirus-like particle vaccine.
Leroux-Roels I, Maes C, Joye J, Jacobs B, Jarczowski F, Diessner A, Janssens Y, Waerlop G, Tamminen K, Heinimäki S, Blazevic V, Leroux-Roels G, Klimyuk V, Adachi H, Hiruta K, Thieme F. Leroux-Roels I, et al. Among authors: klimyuk v. Front Immunol. 2022 Oct 7;13:1021500. doi: 10.3389/fimmu.2022.1021500. eCollection 2022. Front Immunol. 2022. PMID: 36275772 Free PMC article. Clinical Trial.
A plant-expressed conjugate vaccine breaks CD4(+) tolerance and induces potent immunity against metastatic Her2(+) breast cancer.
Chotprakaikiat W, Allen A, Bui-Minh D, Harden E, Jobsri J, Cavallo F, Gleba Y, Stevenson FK, Ottensmeier C, Klimyuk V, Savelyeva N. Chotprakaikiat W, et al. Among authors: klimyuk v. Oncoimmunology. 2016 Apr 22;5(6):e1166323. doi: 10.1080/2162402X.2016.1166323. eCollection 2016 Jun. Oncoimmunology. 2016. PMID: 27471642 Free PMC article.
Clinical Safety and Immunogenicity of Tumor-Targeted, Plant-Made Id-KLH Conjugate Vaccines for Follicular Lymphoma.
Tusé D, Ku N, Bendandi M, Becerra C, Collins R Jr, Langford N, Sancho SI, López-Díaz de Cerio A, Pastor F, Kandzia R, Thieme F, Jarczowski F, Krause D, Ma JK, Pandya S, Klimyuk V, Gleba Y, Butler-Ransohoff JE. Tusé D, et al. Among authors: klimyuk v. Biomed Res Int. 2015;2015:648143. doi: 10.1155/2015/648143. Epub 2015 Sep 6. Biomed Res Int. 2015. PMID: 26425548 Free PMC article. Clinical Trial.
CD28 aptamers as powerful immune response modulators.
Pastor F, Soldevilla MM, Villanueva H, Kolonias D, Inoges S, de Cerio AL, Kandzia R, Klimyuk V, Gleba Y, Gilboa E, Bendandi M. Pastor F, et al. Among authors: klimyuk v. Mol Ther Nucleic Acids. 2013 Jun 11;2(6):e98. doi: 10.1038/mtna.2013.26. Mol Ther Nucleic Acids. 2013. PMID: 23756353 Free PMC article.
Emerging antibody-based products.
Whaley KJ, Morton J, Hume S, Hiatt E, Bratcher B, Klimyuk V, Hiatt A, Pauly M, Zeitlin L. Whaley KJ, et al. Among authors: klimyuk v. Curr Top Microbiol Immunol. 2014;375:107-26. doi: 10.1007/82_2012_240. Curr Top Microbiol Immunol. 2014. PMID: 22772797 Review.
40 results