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Pan-protective anti-alphavirus human antibodies target a conserved E1 protein epitope.
Kim AS, Kafai NM, Winkler ES, Gilliland TC Jr, Cottle EL, Earnest JT, Jethva PN, Kaplonek P, Shah AP, Fong RH, Davidson E, Malonis RJ, Quiroz JA, Williamson LE, Vang L, Mack M, Crowe JE Jr, Doranz BJ, Lai JR, Alter G, Gross ML, Klimstra WB, Fremont DH, Diamond MS. Kim AS, et al. Among authors: klimstra wb. Cell. 2021 Aug 19;184(17):4414-4429.e19. doi: 10.1016/j.cell.2021.07.006. Cell. 2021. PMID: 34416146 Free PMC article.
2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members.
Daffis S, Szretter KJ, Schriewer J, Li J, Youn S, Errett J, Lin TY, Schneller S, Zust R, Dong H, Thiel V, Sen GC, Fensterl V, Klimstra WB, Pierson TC, Buller RM, Gale M Jr, Shi PY, Diamond MS. Daffis S, et al. Among authors: klimstra wb. Nature. 2010 Nov 18;468(7322):452-6. doi: 10.1038/nature09489. Nature. 2010. PMID: 21085181 Free PMC article.
A viral RNA structural element alters host recognition of nonself RNA.
Hyde JL, Gardner CL, Kimura T, White JP, Liu G, Trobaugh DW, Huang C, Tonelli M, Paessler S, Takeda K, Klimstra WB, Amarasinghe GK, Diamond MS. Hyde JL, et al. Among authors: klimstra wb. Science. 2014 Feb 14;343(6172):783-7. doi: 10.1126/science.1248465. Epub 2014 Jan 30. Science. 2014. PMID: 24482115 Free PMC article.
The 5' and 3' ends of alphavirus RNAs--Non-coding is not non-functional.
Hyde JL, Chen R, Trobaugh DW, Diamond MS, Weaver SC, Klimstra WB, Wilusz J. Hyde JL, et al. Among authors: klimstra wb. Virus Res. 2015 Aug 3;206:99-107. doi: 10.1016/j.virusres.2015.01.016. Epub 2015 Jan 25. Virus Res. 2015. PMID: 25630058 Free PMC article. Review.
Mxra8 is a receptor for multiple arthritogenic alphaviruses.
Zhang R, Kim AS, Fox JM, Nair S, Basore K, Klimstra WB, Rimkunas R, Fong RH, Lin H, Poddar S, Crowe JE Jr, Doranz BJ, Fremont DH, Diamond MS. Zhang R, et al. Among authors: klimstra wb. Nature. 2018 May;557(7706):570-574. doi: 10.1038/s41586-018-0121-3. Epub 2018 May 16. Nature. 2018. PMID: 29769725 Free PMC article.
Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein.
Kim AS, Austin SK, Gardner CL, Zuiani A, Reed DS, Trobaugh DW, Sun C, Basore K, Williamson LE, Crowe JE Jr, Slifka MK, Fremont DH, Klimstra WB, Diamond MS. Kim AS, et al. Among authors: klimstra wb. Nat Microbiol. 2019 Jan;4(1):187-197. doi: 10.1038/s41564-018-0286-4. Epub 2018 Nov 19. Nat Microbiol. 2019. PMID: 30455470 Free PMC article.
SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients.
Klimstra WB, Tilston-Lunel NL, Nambulli S, Boslett J, McMillen CM, Gilliland T, Dunn MD, Sun C, Wheeler SE, Wells A, Hartman AL, McElroy AK, Reed DS, Rennick LJ, Duprex WP. Klimstra WB, et al. J Gen Virol. 2020 Nov;101(11):1156-1169. doi: 10.1099/jgv.0.001481. Epub 2020 Aug 21. J Gen Virol. 2020. PMID: 32821033 Free PMC article.
99 results