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Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment.
Lechner L, Opitz R, Silver MJ, Krabusch PM, Prentice AM, Field MS, Stachelscheid H, Leitão E, Schröder C, Fernandez Vallone V, Horsthemke B, Jöckel KH, Schmidt B, Nöthen MM, Hoffmann P, Herms S, Kleyn PW, Megges M, Blume-Peytavi U, Weiss K, Mai K, Blankenstein O, Obermayer B, Wiegand S, Kühnen P. Lechner L, et al. Among authors: kleyn pw. Sci Transl Med. 2023 Jul 19;15(705):eadg1659. doi: 10.1126/scitranslmed.adg1659. Epub 2023 Jul 19. Sci Transl Med. 2023. PMID: 37467315
Comparison of genome screens for two independent cohorts provides replication of suggestive linkage of bone mineral density to 3p21 and 1p36.
Wilson SG, Reed PW, Bansal A, Chiano M, Lindersson M, Langdown M, Prince RL, Thompson D, Thompson E, Bailey M, Kleyn PW, Sambrook P, Shi MM, Spector TD. Wilson SG, et al. Among authors: kleyn pw. Am J Hum Genet. 2003 Jan;72(1):144-55. doi: 10.1086/345819. Epub 2002 Dec 11. Am J Hum Genet. 2003. PMID: 12478480 Free PMC article.
Genetic variation as a guide to drug development.
Kleyn PW, Vesell ES. Kleyn PW, et al. Science. 1998 Sep 18;281(5384):1820-1. doi: 10.1126/science.281.5384.1820. Science. 1998. PMID: 9776686 No abstract available.
21 results