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Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
Georgiadi A, Lopez-Salazar V, Merahbi RE, Karikari RA, Ma X, Mourão A, Klepac K, Bühler L, Alfaro AJ, Kaczmarek I, Linford A, Bosma M, Shilkova O, Ritvos O, Nakamura N, Hirose S, Lassi M, Teperino R, Machado J, Scheideler M, Dietrich A, Geerlof A, Feuchtinger A, Blutke A, Fischer K, Müller TD, Kessler K, Schöneberg T, Thor D, Hornemann S, Kruse M, Nawroth P, Pivovarova-Ramich O, Pfeiffer AFH, Sattler M, Blüher M, Herzig S. Georgiadi A, et al. Among authors: klepac k. Nat Commun. 2021 May 20;12(1):2999. doi: 10.1038/s41467-021-22579-1. Nat Commun. 2021. PMID: 34016966 Free PMC article.
The Gq signalling pathway inhibits brown and beige adipose tissue.
Klepac K, Kilić A, Gnad T, Brown LM, Herrmann B, Wilderman A, Balkow A, Glöde A, Simon K, Lidell ME, Betz MJ, Enerbäck S, Wess J, Freichel M, Blüher M, König G, Kostenis E, Insel PA, Pfeifer A. Klepac K, et al. Nat Commun. 2016 Mar 9;7:10895. doi: 10.1038/ncomms10895. Nat Commun. 2016. PMID: 26955961 Free PMC article.
Lipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic control.
Bühler L, Maida A, Vogl ES, Georgiadi A, Takacs A, Kluth O, Schürmann A, Feuchtinger A, von Toerne C, Tsokanos FF, Klepac K, Wolff G, Sakurai M, Ekim Üstünel B, Nawroth P, Herzig S. Bühler L, et al. Among authors: klepac k. Life Sci Alliance. 2021 Feb 3;4(4):e202000898. doi: 10.26508/lsa.202000898. Print 2021 Apr. Life Sci Alliance. 2021. PMID: 33536239 Free PMC article.
Six-Month Periodic Fasting in Patients With Type 2 Diabetes and Diabetic Nephropathy: A Proof-of-Concept Study.
Sulaj A, Kopf S, von Rauchhaupt E, Kliemank E, Brune M, Kender Z, Bartl H, Cortizo FG, Klepac K, Han Z, Kumar V, Longo V, Teleman A, Okun JG, Morgenstern J, Fleming T, Szendroedi J, Herzig S, Nawroth PP. Sulaj A, et al. Among authors: klepac k. J Clin Endocrinol Metab. 2022 Jul 14;107(8):2167-2181. doi: 10.1210/clinem/dgac197. J Clin Endocrinol Metab. 2022. PMID: 35661214 Free PMC article. Clinical Trial.
Fasting-sensitive SUMO-switch on Prox1 controls hepatic cholesterol metabolism.
Alfaro AJ, Dittner C, Becker J, Loft A, Mhamane A, Maida A, Georgiadi A, Tsokanos FF, Klepac K, Molocea CE, El-Merahbi R, Motzler K, Geppert J, Karikari RA, Szendrödi J, Feuchtinger A, Hofmann S, Karaca S, Urlaub H, Berriel Diaz M, Melchior F, Herzig S. Alfaro AJ, et al. Among authors: klepac k. EMBO Rep. 2023 Oct 9;24(10):e55981. doi: 10.15252/embr.202255981. Epub 2023 Aug 10. EMBO Rep. 2023. PMID: 37560809 Free PMC article.
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