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The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity.
Nat Commun. 2022 Apr 4;13(1):1790. doi: 10.1038/s41467-022-29286-5.
Nat Commun. 2022.
PMID: 35379805
Free PMC article.
Povetacicept, an Enhanced Dual APRIL/BAFF Antagonist That Modulates B Lymphocytes and Pathogenic Autoantibodies for the Treatment of Lupus and Other B Cell-Related Autoimmune Diseases.
Evans LS, Lewis KE, DeMonte D, Bhandari JG, Garrett LB, Kuijper JL, Ardourel D, Wolfson MF, Debrot S, Mudri S, Kleist K, Griffin LL, Hebb L, Sanderson RJ, Wang N, Seaberg M, Chunyk AG, Yang J, Hong Y, Maria Z, Messenheimer DJ, Holland PM, Peng SL, Rixon MW, Dillon SR.
Evans LS, et al.
Arthritis Rheumatol. 2023 Jul;75(7):1187-1202. doi: 10.1002/art.42462. Epub 2023 Apr 19.
Arthritis Rheumatol. 2023.
PMID: 36705554
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Non-Redundant Roles of T Cell Costimulation Pathways in Inflammatory Arthritis Revealed by Dual Blockade of ICOS and CD28 with Acazicolcept (ALPN-101).
Dillon SR, Evans LS, Lewis KE, Debrot S, Blair TC, Mudri S, Kleist K, Levin SD, Bhandari JG, Garrett L, Wolfson MF, Holland PM, Rixon MW, Peng SL.
Dillon SR, et al.
Arthritis Rheumatol. 2023 Aug;75(8):1344-1356. doi: 10.1002/art.42484. Epub 2023 May 9.
Arthritis Rheumatol. 2023.
PMID: 36862144
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ATH-1105, a small-molecule positive modulator of the neurotrophic HGF system, is neuroprotective, preserves neuromotor function, and extends survival in preclinical models of ALS.
Berthiaume AA, Reda SM, Kleist KN, Setti SE, Wu W, Johnston JL, Taylor RW, Stein LR, Moebius HJ, Church KJ.
Berthiaume AA, et al. Among authors: kleist kn.
Front Neurosci. 2024 Feb 8;18:1348157. doi: 10.3389/fnins.2024.1348157. eCollection 2024.
Front Neurosci. 2024.
PMID: 38389786
Free PMC article.
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