Kleinjans JC - Search Results

1

Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis.

van Breda SG, Claessen SM, Lo K, van Herwijnen M, Brauers KJ, Lisanti S, Theunissen DH, Jennen DG, Gaj S, de Kok TM, Kleinjans JC. van Breda SG, et al. Among authors: kleinjans jc. Arch Toxicol. 2015 Nov;89(11):1959-69. doi: 10.1007/s00204-014-1351-2. Epub 2014 Sep 9. Arch Toxicol. 2015. PMID: 25199682

2

New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis.

Souza T, Jennen D, van Delft J, van Herwijnen M, Kyrtoupolos S, Kleinjans J. Souza T, et al. Arch Toxicol. 2016 Jun;90(6):1449-58. doi: 10.1007/s00204-015-1572-z. Epub 2015 Aug 4. Arch Toxicol. 2016. PMID: 26238291 Free PMC article.

3

Molecular signatures of N-nitroso compounds in Caco-2 cells: implications for colon carcinogenesis.

Hebels DG, Jennen DG, Kleinjans JC, de Kok TM. Hebels DG, et al. Among authors: kleinjans jc. Toxicol Sci. 2009 Apr;108(2):290-300. doi: 10.1093/toxsci/kfp035. Epub 2009 Feb 16. Toxicol Sci. 2009. PMID: 19221148

4

Time-series analysis of gene expression profiles induced by nitrosamides and nitrosamines elucidates modes of action underlying their genotoxicity in human colon cells.

Hebels DG, Brauers KJ, van Herwijnen MH, Georgiadis PA, Kyrtopoulos SA, Kleinjans JC, de Kok TM. Hebels DG, et al. Among authors: kleinjans jc. Toxicol Lett. 2011 Dec 15;207(3):232-41. doi: 10.1016/j.toxlet.2011.09.012. Epub 2011 Sep 19. Toxicol Lett. 2011. PMID: 21946166

5

'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans.

Jetten MJ, Gaj S, Ruiz-Aracama A, de Kok TM, van Delft JH, Lommen A, van Someren EP, Jennen DG, Claessen SM, Peijnenburg AA, Stierum RH, Kleinjans JC. Jetten MJ, et al. Among authors: kleinjans jc. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):320-8. doi: 10.1016/j.taap.2012.01.009. Epub 2012 Jan 20. Toxicol Appl Pharmacol. 2012. PMID: 22285215 Clinical Trial.

6

Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain.

Jiang J, Briedé JJ, Jennen DG, Van Summeren A, Saritas-Brauers K, Schaart G, Kleinjans JC, de Kok TM. Jiang J, et al. Among authors: kleinjans jc. Toxicol Lett. 2015 Apr 16;234(2):139-50. doi: 10.1016/j.toxlet.2015.02.012. Epub 2015 Feb 19. Toxicol Lett. 2015. PMID: 25704631

7

Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes.

Jetten MJ, Ruiz-Aracama A, Coonen ML, Claessen SM, van Herwijnen MH, Lommen A, van Delft JH, Peijnenburg AA, Kleinjans JC. Jetten MJ, et al. Among authors: kleinjans jc. Arch Toxicol. 2016 May;90(5):1103-15. doi: 10.1007/s00204-015-1545-2. Epub 2015 Jun 24. Arch Toxicol. 2016. PMID: 26104854 Free PMC article.

8

Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma.

Rieswijk L, Claessen SM, Bekers O, van Herwijnen M, Theunissen DH, Jennen DG, de Kok TM, Kleinjans JC, van Breda SG. Rieswijk L, et al. Among authors: kleinjans jc. Toxicology. 2016 Mar 28;350-352:31-9. doi: 10.1016/j.tox.2016.05.002. Epub 2016 May 3. Toxicology. 2016. PMID: 27153756

9

Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis.

Wolters JE, van Herwijnen MH, Theunissen DH, Jennen DG, Van den Hof WF, de Kok TM, Schaap FG, van Breda SG, Kleinjans JC. Wolters JE, et al. Among authors: kleinjans jc. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174. doi: 10.1021/acs.chemrestox.6b00337. Epub 2016 Dec 2. Chem Res Toxicol. 2016. PMID: 27989131

10

DTNI: a novel toxicogenomics data analysis tool for identifying the molecular mechanisms underlying the adverse effects of toxic compounds.

Hendrickx DM, Souza T, Jennen DGJ, Kleinjans JCS. Hendrickx DM, et al. Arch Toxicol. 2017 Jun;91(6):2343-2352. doi: 10.1007/s00204-016-1922-5. Epub 2016 Dec 28. Arch Toxicol. 2017. PMID: 28032149 Free PMC article.

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