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In vitro drug release, mechanical performance and stability testing of a custom silicone elastomer vaginal ring releasing dapivirine and levonorgestrel.
Murphy DJ, Dallal Bashi YH, McCoy CF, Boyd P, Brown L, Martin F, McMullen N, Kleinbeck K, Dangi B, Spence P, Hansraj B, Devlin B, Malcolm RK. Murphy DJ, et al. Among authors: kleinbeck k. Int J Pharm X. 2022 Jan 25;4:100112. doi: 10.1016/j.ijpx.2022.100112. eCollection 2022 Dec. Int J Pharm X. 2022. PMID: 35128382 Free PMC article.
Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel.
Dallal Bashi YH, Murphy DJ, McCoy CF, Boyd P, Brown L, Kihara M, Martin F, McMullen N, Kleinbeck K, Dangi B, Spence P, Hansraj B, Devlin B, Malcolm RK. Dallal Bashi YH, et al. Among authors: kleinbeck k. Int J Pharm X. 2021 Jul 14;3:100091. doi: 10.1016/j.ijpx.2021.100091. eCollection 2021 Dec. Int J Pharm X. 2021. PMID: 34977558 Free PMC article.
Results of a phase 1, randomized, placebo-controlled first-in-human trial of griffithsin formulated in a carrageenan vaginal gel.
Teleshova N, Keller MJ, Fernández Romero JA, Friedland BA, Creasy GW, Plagianos MG, Ray L, Barnable P, Kizima L, Rodriguez A, Cornejal N, Melo C, Cruz Rodriguez G, Mukhopadhyay S, Calenda G, Sinkar SU, Bonnaire T, Wesenberg A, Zhang S, Kleinbeck K, Palmer K, Alami M, O'Keefe BR, Gillevet P, Hur H, Liang Y, Santone G, Fichorova RN, Kalir T, Zydowsky TM. Teleshova N, et al. Among authors: kleinbeck k. PLoS One. 2022 Jan 20;17(1):e0261775. doi: 10.1371/journal.pone.0261775. eCollection 2022. PLoS One. 2022. PMID: 35051209 Free PMC article. Clinical Trial.
Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo.
Derby N, Lal M, Aravantinou M, Kizima L, Barnable P, Rodriguez A, Lai M, Wesenberg A, Ugaonkar S, Levendosky K, Mizenina O, Kleinbeck K, Lifson JD, Peet MM, Lloyd Z, Benson M, Heneine W, O'Keefe BR, Robbiani M, Martinelli E, Grasperge B, Blanchard J, Gettie A, Teleshova N, Fernández-Romero JA, Zydowsky TM. Derby N, et al. Among authors: kleinbeck k. Nat Commun. 2018 Sep 24;9(1):3881. doi: 10.1038/s41467-018-06349-0. Nat Commun. 2018. PMID: 30250170 Free PMC article.
First-in-Human Trial of MIV-150 and Zinc Acetate Coformulated in a Carrageenan Gel: Safety, Pharmacokinetics, Acceptability, Adherence, and Pharmacodynamics.
Friedland BA, Hoesley CJ, Plagianos M, Hoskin E, Zhang S, Teleshova N, Alami M, Novak L, Kleinbeck KR, Katzen LL, Zydowsky TM, Fernández-Romero JA, Creasy GW. Friedland BA, et al. Among authors: kleinbeck kr. J Acquir Immune Defic Syndr. 2016 Dec 15;73(5):489-496. doi: 10.1097/QAI.0000000000001136. J Acquir Immune Defic Syndr. 2016. PMID: 27437826 Free PMC article. Clinical Trial.
Correction: A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3.
Arrode-Brusés G, Goode D, Kleinbeck K, Wilk J, Frank I, Byrareddy S, Arthos J, Grasperge B, Blanchard J, Zydowsky T, Gettie A, Martinelli E. Arrode-Brusés G, et al. Among authors: kleinbeck k. PLoS Pathog. 2016 Jul 14;12(7):e1005781. doi: 10.1371/journal.ppat.1005781. eCollection 2016 Jul. PLoS Pathog. 2016. PMID: 27415435 Free PMC article.
25 results