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Application of Transition-Metal Catalysis, Biocatalysis, and Flow Chemistry as State-of-the-Art Technologies in the Synthesis of LCZ696.
Gu X, Zhao J, Chen L, Li Y, Yu B, Tian X, Min Z, Xu S, Gu H, Sun J, Lu X, Chang M, Wang X, Zhao L, Ye S, Yang H, Tian Y, Gao F, Gai Y, Jia G, Wu J, Wang Y, Zhang J, Zhang X, Liu W, Gu X, Luo X, Dong H, Wang H, Schenkel B, Venturoni F, Filipponi P, Guelat B, Allmendinger T, Wietfeld B, Hoehn P, Kovacic N, Hermann L, Schlama T, Ruch T, Derrien N, Piechon P, Kleinbeck F. Gu X, et al. Among authors: kleinbeck f. J Org Chem. 2020 Jun 5;85(11):6844-6853. doi: 10.1021/acs.joc.0c00473. Epub 2020 May 15. J Org Chem. 2020. PMID: 32412751
Total synthesis of bafilomycin A1.
Kleinbeck F, Carreira EM. Kleinbeck F, et al. Angew Chem Int Ed Engl. 2009;48(3):578-81. doi: 10.1002/anie.200804645. Angew Chem Int Ed Engl. 2009. PMID: 19067440 No abstract available.
Total synthesis of bafilomycin A1.
Kleinbeck F, Fettes GJ, Fader LD, Carreira EM. Kleinbeck F, et al. Chemistry. 2012 Mar 19;18(12):3598-610. doi: 10.1002/chem.201102797. Epub 2012 Feb 16. Chemistry. 2012. PMID: 22344969