Kleinau G - Search Results

1

Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-α-MSH and setmelanotide.

Heyder NA, Kleinau G, Speck D, Schmidt A, Paisdzior S, Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D, Bürger J, Mielke T, Beck-Sickinger AG, Hildebrand PW, Spahn CMT, Hilger D, Schacherl M, Biebermann H, Hilal T, Kühnen P, Kobilka BK, Scheerer P. Heyder NA, et al. Among authors: kleinau g. Cell Res. 2021 Nov;31(11):1176-1189. doi: 10.1038/s41422-021-00569-8. Epub 2021 Sep 24. Cell Res. 2021. PMID: 34561620 Free PMC article.

2

A heterozygous mutation in the third transmembrane domain causes a dominant-negative effect on signalling capability of the MC4R.

Tarnow P, Rediger A, Brumm H, Ambrugger P, Rettenbacher E, Widhalm K, Hinney A, Kleinau G, Schaefer M, Hebebrand J, Krause G, Grüters A, Biebermann H. Tarnow P, et al. Among authors: kleinau g. Obes Facts. 2008;1(3):155-62. doi: 10.1159/000138251. Epub 2008 Jun 20. Obes Facts. 2008. PMID: 20054175 Free PMC article.

3

A new phenotype of nongoitrous and nonautoimmune hyperthyroidism caused by a heterozygous thyrotropin receptor mutation in transmembrane helix 6.

Winkler F, Kleinau G, Tarnow P, Rediger A, Grohmann L, Gaetjens I, Krause G, L'Allemand D, Grüters A, Krude H, Biebermann H. Winkler F, et al. Among authors: kleinau g. J Clin Endocrinol Metab. 2010 Aug;95(8):3605-10. doi: 10.1210/jc.2010-0112. Epub 2010 May 25. J Clin Endocrinol Metab. 2010. PMID: 20501679

4

Genetic defects, thyroid growth and malfunctions of the TSHR in pediatric patients.

Biebermann H, Winkler F, Kleinau G. Biebermann H, et al. Among authors: kleinau g. Front Biosci (Landmark Ed). 2010 Jun 1;15(3):913-33. doi: 10.2741/3654. Front Biosci (Landmark Ed). 2010. PMID: 20515734 Free article. Review.

5

Insights into molecular properties of the human monocarboxylate transporter 8 by combining functional with structural information.

Kleinau G, Schweizer U, Kinne A, Köhrle J, Grüters A, Krude H, Biebermann H. Kleinau G, et al. Thyroid Res. 2011 Aug 3;4 Suppl 1(Suppl 1):S4. doi: 10.1186/1756-6614-4-S1-S4. Thyroid Res. 2011. PMID: 21835051 Free PMC article.

6

Molecular description of non-autoimmune hyperthyroidism at a neonate caused by a new thyrotropin receptor germline mutation.

Biebermann H, Winkler F, Handke D, Grüters A, Krude H, Kleinau G. Biebermann H, et al. Among authors: kleinau g. Thyroid Res. 2011 Aug 3;4 Suppl 1(Suppl 1):S8. doi: 10.1186/1756-6614-4-S1-S8. Thyroid Res. 2011. PMID: 21835055 Free PMC article.

7

Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptors.

Rediger A, Piechowski CL, Yi CX, Tarnow P, Strotmann R, Grüters A, Krude H, Schöneberg T, Tschöp MH, Kleinau G, Biebermann H. Rediger A, et al. Among authors: kleinau g. J Biol Chem. 2011 Nov 11;286(45):39623-31. doi: 10.1074/jbc.M111.287607. Epub 2011 Sep 22. J Biol Chem. 2011. PMID: 21940628 Free PMC article.

8

Differential modulation of Beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonists.

Kleinau G, Pratzka J, Nürnberg D, Grüters A, Führer-Sakel D, Krude H, Köhrle J, Schöneberg T, Biebermann H. Kleinau G, et al. PLoS One. 2011;6(10):e27073. doi: 10.1371/journal.pone.0027073. Epub 2011 Oct 31. PLoS One. 2011. PMID: 22073124 Free PMC article.

9

New pathogenic thyrotropin receptor mutations decipher differentiated activity switching at a conserved helix 6 motif of family A GPCR.

Biebermann H, Winkler F, Handke D, Teichmann A, Gerling B, Cameron F, Eichhorst J, Grüters A, Wiesner B, Kühnen P, Krude H, Kleinau G. Biebermann H, et al. Among authors: kleinau g. J Clin Endocrinol Metab. 2012 Feb;97(2):E228-32. doi: 10.1210/jc.2011-2106. Epub 2011 Nov 23. J Clin Endocrinol Metab. 2012. PMID: 22112806

10

The neuroendocrine circuitry controlled by POMC, MSH, and AGRP.

Biebermann H, Kühnen P, Kleinau G, Krude H. Biebermann H, et al. Among authors: kleinau g. Handb Exp Pharmacol. 2012;(209):47-75. doi: 10.1007/978-3-642-24716-3_3. Handb Exp Pharmacol. 2012. PMID: 22249810 Review.

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