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Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure.
Busnelli M, Kleinau G, Muttenthaler M, Stoev S, Manning M, Bibic L, Howell LA, McCormick PJ, Di Lascio S, Braida D, Sala M, Rovati GE, Bellini T, Chini B. Busnelli M, et al. Among authors: kleinau g. J Med Chem. 2016 Aug 11;59(15):7152-66. doi: 10.1021/acs.jmedchem.6b00564. Epub 2016 Jul 28. J Med Chem. 2016. PMID: 27420737 Free article.
Germline prokineticin receptor 2 (PROKR2) variants associated with central hypogonadism cause differental modulation of distinct intracellular pathways.
Libri DV, Kleinau G, Vezzoli V, Busnelli M, Guizzardi F, Sinisi AA, Pincelli AI, Mancini A, Russo G, Beck-Peccoz P, Loche S, Crivellaro C, Maghnie M, Krausz C, Persani L, Bonomi M; Italian Study Group on Idiopathic Central Hypogonadism (ICH). Libri DV, et al. Among authors: kleinau g. J Clin Endocrinol Metab. 2014 Mar;99(3):E458-63. doi: 10.1210/jc.2013-2431. Epub 2013 Nov 25. J Clin Endocrinol Metab. 2014. PMID: 24276467 Free article.
Loss-of-Function Variants in a Hungarian Cohort Reveal Structural Insights on TSH Receptor Maturation and Signaling.
Lábadi Á, Grassi ES, Gellén B, Kleinau G, Biebermann H, Ruzsa B, Gelmini G, Rideg O, Miseta A, Kovács GL, Patócs A, Felszeghy E, Nagy EV, Mezősi E, Persani L. Lábadi Á, et al. Among authors: kleinau g. J Clin Endocrinol Metab. 2015 Jul;100(7):E1039-45. doi: 10.1210/jc.2014-4511. Epub 2015 May 15. J Clin Endocrinol Metab. 2015. PMID: 25978107
Non-Functional Trace Amine-Associated Receptor 1 Variants in Patients With Mental Disorders.
Rutigliano G, Bräunig J, Del Grande C, Carnicelli V, Masci I, Merlino S, Kleinau G, Tessieri L, Pardossi S, Paisdzior S, Dell'Osso L, Biebermann H, Zucchi R. Rutigliano G, et al. Among authors: kleinau g. Front Pharmacol. 2019 Sep 13;10:1027. doi: 10.3389/fphar.2019.01027. eCollection 2019. Front Pharmacol. 2019. PMID: 31572197 Free PMC article.
Urolinin: The First Linear Peptidic Urotensin-II Receptor Agonist.
Bandholtz S, Erdmann S, von Hacht JL, Exner S, Krause G, Kleinau G, Grötzinger C. Bandholtz S, et al. Among authors: kleinau g. J Med Chem. 2016 Nov 23;59(22):10100-10112. doi: 10.1021/acs.jmedchem.6b00164. Epub 2016 Nov 4. J Med Chem. 2016. PMID: 27791374
Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns.
Moore S, Jaeschke H, Kleinau G, Neumann S, Costanzi S, Jiang JK, Childress J, Raaka BM, Colson A, Paschke R, Krause G, Thomas CJ, Gershengorn MC. Moore S, et al. Among authors: kleinau g. J Med Chem. 2006 Jun 29;49(13):3888-96. doi: 10.1021/jm060247s. J Med Chem. 2006. PMID: 16789744 Free PMC article.
New pathogenic thyrotropin receptor mutations decipher differentiated activity switching at a conserved helix 6 motif of family A GPCR.
Biebermann H, Winkler F, Handke D, Teichmann A, Gerling B, Cameron F, Eichhorst J, Grüters A, Wiesner B, Kühnen P, Krude H, Kleinau G. Biebermann H, et al. Among authors: kleinau g. J Clin Endocrinol Metab. 2012 Feb;97(2):E228-32. doi: 10.1210/jc.2011-2106. Epub 2011 Nov 23. J Clin Endocrinol Metab. 2012. PMID: 22112806
118 results