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17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development.
Marchais-Oberwinkler S, Henn C, Möller G, Klein T, Negri M, Oster A, Spadaro A, Werth R, Wetzel M, Xu K, Frotscher M, Hartmann RW, Adamski J. Marchais-Oberwinkler S, et al. Among authors: klein t. J Steroid Biochem Mol Biol. 2011 May;125(1-2):66-82. doi: 10.1016/j.jsbmb.2010.12.013. Epub 2010 Dec 28. J Steroid Biochem Mol Biol. 2011. PMID: 21193039 Review.
New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitory activity and selectivity.
Bey E, Marchais-Oberwinkler S, Negri M, Kruchten P, Oster A, Klein T, Spadaro A, Werth R, Frotscher M, Birk B, Hartmann RW. Bey E, et al. Among authors: klein t. J Med Chem. 2009 Nov 12;52(21):6724-43. doi: 10.1021/jm901195w. J Med Chem. 2009. PMID: 19831396
Novel estrone mimetics with high 17beta-HSD1 inhibitory activity.
Oster A, Klein T, Werth R, Kruchten P, Bey E, Negri M, Marchais-Oberwinkler S, Frotscher M, Hartmann RW. Oster A, et al. Among authors: klein t. Bioorg Med Chem. 2010 May 15;18(10):3494-505. doi: 10.1016/j.bmc.2010.03.065. Epub 2010 Mar 29. Bioorg Med Chem. 2010. PMID: 20413314
Generating Clinical-Grade Gene-Disease Validity Classifications Through the ClinGen Data Platforms.
Wright MW, Thaxton CL, Nelson T, DiStefano MT, Savatt JM, Brush MH, Cheung G, Mandell ME, Wulf B, Ward TJ, Goehringer S, O'Neill T, Weller P, Preston CG, Keseler IM, Goldstein JL, Strande NT, McGlaughon J, Azzariti DR, Cordova I, Dziadzio H, Babb L, Riehle K, Milosavljevic A, Martin CL, Rehm HL, Plon SE, Berg JS, Riggs ER, Klein TE. Wright MW, et al. Among authors: klein te. Annu Rev Biomed Data Sci. 2024 Apr 25. doi: 10.1146/annurev-biodatasci-102423-112456. Online ahead of print. Annu Rev Biomed Data Sci. 2024. PMID: 38663031 Review.
2,063 results