Klein P - Search Results

1

The Pharmacology and Clinical Efficacy of Antiseizure Medications: From Bromide Salts to Cenobamate and Beyond.

Löscher W, Klein P. Löscher W, et al. Among authors: klein p. CNS Drugs. 2021 Sep;35(9):935-963. doi: 10.1007/s40263-021-00827-8. Epub 2021 Jun 18. CNS Drugs. 2021. PMID: 34145528 Free PMC article. Review.

2

Brivaracetam for the treatment of epilepsy.

Klein P, Tyrlikova I, Brazdil M, Rektor I. Klein P, et al. Expert Opin Pharmacother. 2016;17(2):283-95. doi: 10.1517/14656566.2016.1135129. Epub 2016 Jan 13. Expert Opin Pharmacother. 2016. PMID: 26760311 Review.

3

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks-Kayal AR, Engel J Jr, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, Pearl PL, Pitkänen A, Puhakka N, Rogawski MA, Schmidt D, Sillanpää M, Sloviter RS, Steinhäuser C, Vezzani A, Walker MC, Löscher W. Klein P, et al. Epilepsia. 2018 Jan;59(1):37-66. doi: 10.1111/epi.13965. Epub 2017 Dec 15. Epilepsia. 2018. PMID: 29247482 Free PMC article. Review.

4

Network pharmacology for antiepileptogenesis: Tolerability and neuroprotective effects of novel multitargeted combination treatments in nonepileptic vs. post-status epilepticus mice.

Welzel L, Twele F, Schidlitzki A, Töllner K, Klein P, Löscher W. Welzel L, et al. Among authors: klein p. Epilepsy Res. 2019 Mar;151:48-66. doi: 10.1016/j.eplepsyres.2019.02.010. Epub 2019 Feb 25. Epilepsy Res. 2019. PMID: 30831337

5

Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial.

Krauss GL, Klein P, Brandt C, Lee SK, Milanov I, Milovanovic M, Steinhoff BJ, Kamin M. Krauss GL, et al. Among authors: klein p. Lancet Neurol. 2020 Jan;19(1):38-48. doi: 10.1016/S1474-4422(19)30399-0. Epub 2019 Nov 14. Lancet Neurol. 2020. PMID: 31734103 Clinical Trial.

6

Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?

Klein P, Friedman A, Hameed MQ, Kaminski RM, Bar-Klein G, Klitgaard H, Koepp M, Jozwiak S, Prince DA, Rotenberg A, Twyman R, Vezzani A, Wong M, Löscher W. Klein P, et al. Epilepsia. 2020 Mar;61(3):359-386. doi: 10.1111/epi.16450. Epilepsia. 2020. PMID: 32196665 Free PMC article. Review.

7

The feast and famine: Epilepsy treatment and treatment gaps in early 21st century.

Löscher W, Klein P. Löscher W, et al. Among authors: klein p. Neuropharmacology. 2020 Jun 15;170:108055. doi: 10.1016/j.neuropharm.2020.108055. Epub 2020 Mar 19. Neuropharmacology. 2020. PMID: 32199986 No abstract available.

8

Cenobamate (YKP3089) as adjunctive treatment for uncontrolled focal seizures in a large, phase 3, multicenter, open-label safety study.

Sperling MR, Klein P, Aboumatar S, Gelfand M, Halford JJ, Krauss GL, Rosenfeld WE, Vossler DG, Wechsler R, Borchert L, Kamin M. Sperling MR, et al. Among authors: klein p. Epilepsia. 2020 Jun;61(6):1099-1108. doi: 10.1111/epi.16525. Epub 2020 May 12. Epilepsia. 2020. PMID: 32396252 Free PMC article. Clinical Trial.

9

Systematic evaluation of rationally chosen multitargeted drug combinations: a combination of low doses of levetiracetam, atorvastatin and ceftriaxone exerts antiepileptogenic effects in a mouse model of acquired epilepsy.

Welzel L, Bergin DH, Schidlitzki A, Twele F, Johne M, Klein P, Löscher W. Welzel L, et al. Among authors: klein p. Neurobiol Dis. 2021 Feb;149:105227. doi: 10.1016/j.nbd.2020.105227. Epub 2020 Dec 19. Neurobiol Dis. 2021. PMID: 33347976 Free article.

10

New approaches for developing multi-targeted drug combinations for disease modification of complex brain disorders. Does epilepsy prevention become a realistic goal?

Löscher W, Klein P. Löscher W, et al. Among authors: klein p. Pharmacol Ther. 2022 Jan;229:107934. doi: 10.1016/j.pharmthera.2021.107934. Epub 2021 Jun 30. Pharmacol Ther. 2022. PMID: 34216705 Review.

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