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An Antiherpesviral Host-Directed Strategy Based on CDK7 Covalently Binding Drugs: Target-Selective, Picomolar-Dose, Cross-Virus Reactivity.
Yu D, Wagner S, Schütz M, Jeon Y, Seo M, Kim J, Brückner N, Kicuntod J, Tillmanns J, Wangen C, Hahn F, Kaufer BB, Neipel F, Eickhoff J, Klebl B, Nam K, Marschall M. Yu D, et al. Among authors: klebl b. Pharmaceutics. 2024 Jan 23;16(2):158. doi: 10.3390/pharmaceutics16020158. Pharmaceutics. 2024. PMID: 38399219 Free PMC article.
Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency.
Schütz M, Wangen C, Sommerer M, Kögler M, Eickhoff J, Degenhart C, Klebl B, Naing Z, Egilmezer E, Hamilton ST, Rawlinson WD, Sticht H, Marschall M. Schütz M, et al. Among authors: klebl b. Virus Res. 2023 Oct 2;335:199200. doi: 10.1016/j.virusres.2023.199200. Epub 2023 Aug 19. Virus Res. 2023. PMID: 37591314 Free PMC article.
Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form.
Aarhus TI, Bjørnstad F, Wolowczyk C, Larsen KU, Rognstad L, Leithaug T, Unger A, Habenberger P, Wolf A, Bjørkøy G, Pridans C, Eickhoff J, Klebl B, Hoff BH, Sundby E. Aarhus TI, et al. Among authors: klebl b. J Med Chem. 2023 May 25;66(10):6959-6980. doi: 10.1021/acs.jmedchem.3c00428. Epub 2023 May 16. J Med Chem. 2023. PMID: 37191268 Free PMC article.
Pyrrolopyrimidine based CSF1R inhibitors: Attempted departure from Flatland.
Bjørnstad F, Havik S, Aarhus TI, Mahdi I, Unger A, Habenberger P, Degenhart C, Eickhoff J, Klebl BM, Sundby E, Hoff BH. Bjørnstad F, et al. Among authors: klebl bm. Eur J Med Chem. 2024 Feb 5;265:116053. doi: 10.1016/j.ejmech.2023.116053. Epub 2023 Dec 17. Eur J Med Chem. 2024. PMID: 38141285 Free article.
IFNα primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization.
Andlovic B, Heilmann G, Ninck S, Andrei SA, Centorrino F, Higuchi Y, Kato N, Brunsveld L, Arkin M, Menninger S, Choidas A, Wolf A, Klebl B, Kaschani F, Kaiser M, Eickhoff J, Ottmann C. Andlovic B, et al. Among authors: klebl b. Cell Chem Biol. 2023 Jun 15;30(6):573-590.e6. doi: 10.1016/j.chembiol.2023.04.005. Epub 2023 May 1. Cell Chem Biol. 2023. PMID: 37130519
A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening.
Kaufmann J, Blum NK, Nagel F, Schuler A, Drube J, Degenhart C, Engel J, Eickhoff JE, Dasgupta P, Fritzwanker S, Guastadisegni M, Schulte C, Miess-Tanneberg E, Maric HM, Spetea M, Kliewer A, Baumann M, Klebl B, Reinscheid RK, Hoffmann C, Schulz S. Kaufmann J, et al. Among authors: klebl b. Commun Biol. 2022 Nov 9;5(1):1206. doi: 10.1038/s42003-022-04135-9. Commun Biol. 2022. PMID: 36352263 Free PMC article.
ComplexEye: a multi-lens array microscope for high-throughput embedded immune cell migration analysis.
Cibir Z, Hassel J, Sonneck J, Kowitz L, Beer A, Kraus A, Hallekamp G, Rosenkranz M, Raffelberg P, Olfen S, Smilowski K, Burkard R, Helfrich I, Tuz AA, Singh V, Ghosh S, Sickmann A, Klebl AK, Eickhoff JE, Klebl B, Seidl K, Chen J, Grabmaier A, Viga R, Gunzer M. Cibir Z, et al. Among authors: klebl b. Nat Commun. 2023 Dec 11;14(1):8103. doi: 10.1038/s41467-023-43765-3. Nat Commun. 2023. PMID: 38081825 Free PMC article.
72 results