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Licogliflozin for nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a study.
Harrison SA, Manghi FP, Smith WB, Alpenidze D, Aizenberg D, Klarenbeek N, Chen CY, Zuckerman E, Ravussin E, Charatcharoenwitthaya P, Cheng PN, Katchman H, Klein S, Ben-Ari Z, Mendonza AE, Zhang Y, Martic M, Ma S, Kao S, Tanner S, Pachori A, Badman MK, He Y, Ukomadu C, Sicard E. Harrison SA, et al. Among authors: klarenbeek n. Nat Med. 2022 Jul;28(7):1432-1438. doi: 10.1038/s41591-022-01861-9. Epub 2022 Jun 20. Nat Med. 2022. PMID: 35725922 Free PMC article. Clinical Trial.
Immunosuppression by hydroxychloroquine: mechanistic proof in in vitro experiments but limited systemic activity in a randomized placebo-controlled clinical pharmacology study.
In 't Veld AE, Grievink HW, van der Plas JL, Eveleens Maarse BC, van Kraaij SJW, Woutman TD, Schoonakker M, Klarenbeek NB, de Kam ML, Kamerling IMC, Jansen MAA, Moerland M. In 't Veld AE, et al. Among authors: klarenbeek nb. Immunol Res. 2023 Aug;71(4):617-627. doi: 10.1007/s12026-023-09367-3. Epub 2023 Feb 22. Immunol Res. 2023. PMID: 36811819 Free PMC article. Clinical Trial.
Risk of alanine transferase (ALT) elevation in patients with rheumatoid arthritis treated with methotrexate in a DAS-steered strategy.
Dirven L, Klarenbeek NB, van den Broek M, van Groenendael JH, de Sonnaville PB, Kerstens PJ, Huizinga TW, Dijkmans BA, Lems WF, Allaart CF. Dirven L, et al. Among authors: klarenbeek nb. Clin Rheumatol. 2013 May;32(5):585-90. doi: 10.1007/s10067-012-2136-8. Epub 2012 Dec 9. Clin Rheumatol. 2013. PMID: 23224330 Clinical Trial.
Oral prednisolone suppresses skin inflammation in a healthy volunteer imiquimod challenge model.
Assil S, Buters TP, Hameeteman PW, Hallard C, Treijtel N, Niemeyer-Van der Kolk T, de Kam ML, Florencia EFIII, Prens EP, van Doorn MBA, Rissmann R, Klarenbeek NB, Jansen MAA, Moerland M. Assil S, et al. Among authors: klarenbeek nb. Front Immunol. 2023 Jul 20;14:1197650. doi: 10.3389/fimmu.2023.1197650. eCollection 2023. Front Immunol. 2023. PMID: 37545524 Free PMC article. Clinical Trial.
A decrease in disease activity score (DAS) level is associated with a decrease in health assessment questionnaire (HAQ) score, independent of follow-up duration, during 5 years of tightly controlled treatment: results from the BeSt study.
van der Kooi E, Klarenbeek NB, Güler-Yüksel M, Kerstens PJ, van der Lubbe PA, Westedt ML, ten Wolde S, Huizinga TW, Dijkmans BA, Allaart CF. van der Kooi E, et al. Among authors: klarenbeek nb. Ann Rheum Dis. 2011 Jan;70(1):168-71. doi: 10.1136/ard.2010.133132. Epub 2010 Nov 29. Ann Rheum Dis. 2011. PMID: 21115551
Guselkumab induction therapy demonstrates long-lasting efficacy in patients with mild psoriasis, results from a randomized, placebo-controlled exploratory clinical trial.
Rousel J, Bergmans ME, van der Meulen LWJ, Pagan L, de Bruin DT, de Kam ML, Klarenbeek NB, Bouwstra JA, Seyger MMB, van den Reek JMPA, Niemeyer-van der Kolk T, Rissmann R, van Doorn MBA; NGID consortium. Rousel J, et al. Among authors: klarenbeek nb. J Am Acad Dermatol. 2024 Feb;90(2):395-397. doi: 10.1016/j.jaad.2023.09.071. Epub 2023 Oct 5. J Am Acad Dermatol. 2024. PMID: 37804933 Free article. Clinical Trial. No abstract available.
A novel sustained-release cysteamine bitartrate formulation for the treatment of cystinosis: Pharmacokinetics and safety in healthy male volunteers.
Berends CL, Pagan L, van Esdonk MJ, Klarenbeek NB, Bergmann KR, Moerland M, van der Wel V, de Visser SJ, Büller H, de Loos F, de Vries WS, Waals H, de Leede LGJ, Burggraaf J, Kamerling IMC. Berends CL, et al. Pharmacol Res Perspect. 2021 Apr;9(2):e00739. doi: 10.1002/prp2.739. Pharmacol Res Perspect. 2021. PMID: 33764642 Free PMC article. Clinical Trial.
The BeSt story: on strategy trials in rheumatoid arthritis.
Klarenbeek NB, Allaart CF, Kerstens PJ, Huizinga TW, Dijkmans BA. Klarenbeek NB, et al. Curr Opin Rheumatol. 2009 May;21(3):291-8. doi: 10.1097/BOR.0b013e32832a2f1c. Curr Opin Rheumatol. 2009. PMID: 19318946 Review.
35 results