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NAD+ repletion with niacin counteracts cancer cachexia.
Beltrà M, Pöllänen N, Fornelli C, Tonttila K, Hsu MY, Zampieri S, Moletta L, Corrà S, Porporato PE, Kivelä R, Viscomi C, Sandri M, Hulmi JJ, Sartori R, Pirinen E, Penna F. Beltrà M, et al. Among authors: kivela r. Nat Commun. 2023 Apr 3;14(1):1849. doi: 10.1038/s41467-023-37595-6. Nat Commun. 2023. PMID: 37012289 Free PMC article.
VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart.
Kivelä R, Bry M, Robciuc MR, Räsänen M, Taavitsainen M, Silvola JM, Saraste A, Hulmi JJ, Anisimov A, Mäyränpää MI, Lindeman JH, Eklund L, Hellberg S, Hlushchuk R, Zhuang ZW, Simons M, Djonov V, Knuuti J, Mervaala E, Alitalo K. Kivelä R, et al. EMBO Mol Med. 2014 Mar;6(3):307-21. doi: 10.1002/emmm.201303147. Epub 2014 Jan 21. EMBO Mol Med. 2014. PMID: 24448490 Free PMC article.
Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling.
Holopainen T, Räsänen M, Anisimov A, Tuomainen T, Zheng W, Tvorogov D, Hulmi JJ, Andersson LC, Cenni B, Tavi P, Mervaala E, Kivelä R, Alitalo K. Holopainen T, et al. Among authors: kivela r. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):13063-8. doi: 10.1073/pnas.1517810112. Epub 2015 Oct 1. Proc Natl Acad Sci U S A. 2015. PMID: 26430242 Free PMC article.
VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection.
Räsänen M, Degerman J, Nissinen TA, Miinalainen I, Kerkelä R, Siltanen A, Backman JT, Mervaala E, Hulmi JJ, Kivelä R, Alitalo K. Räsänen M, et al. Among authors: kivela r. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13144-13149. doi: 10.1073/pnas.1616168113. Epub 2016 Oct 31. Proc Natl Acad Sci U S A. 2016. PMID: 27799559 Free PMC article.
Prevention of chemotherapy-induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle.
Hulmi JJ, Nissinen TA, Räsänen M, Degerman J, Lautaoja JH, Hemanthakumar KA, Backman JT, Ritvos O, Silvennoinen M, Kivelä R. Hulmi JJ, et al. Among authors: kivela r. J Cachexia Sarcopenia Muscle. 2018 Apr;9(2):417-432. doi: 10.1002/jcsm.12265. Epub 2017 Dec 11. J Cachexia Sarcopenia Muscle. 2018. PMID: 29230965 Free PMC article.
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