Kitson RRA - Search Results

1

2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1.

Finger V, Kucera T, Kafkova R, Muckova L, Dolezal R, Kubes J, Novak M, Prchal L, Lakatos L, Andrs M, Hympanova M, Marek J, Kufa M, Spiwok V, Soukup O, Mezeiova E, Janousek J, Nevosadova L, Benkova M, Kitson RRA, Kratky M, Bősze S, Mikusova K, Hartkoorn R, Roh J, Korabecny J. Finger V, et al. Among authors: kitson rra. Eur J Med Chem. 2023 Oct 5;258:115611. doi: 10.1016/j.ejmech.2023.115611. Epub 2023 Jul 3. Eur J Med Chem. 2023. PMID: 37421887 Free article.

2

Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway.

Karabanovich G, Fabiánová V, Vocat A, Dušek J, Valášková L, Stolaříková J, Kitson RRA, Pávek P, Vávrová K, Djaout K, Mikušová K, Baulard AR, Cole ST, Korduláková J, Roh J. Karabanovich G, et al. Among authors: kitson rra. J Med Chem. 2024 Jan 11;67(1):81-109. doi: 10.1021/acs.jmedchem.3c00925. Epub 2023 Dec 29. J Med Chem. 2024. PMID: 38157261 Free PMC article.

3

Formal Total Synthesis of Diazonamide A by Indole Oxidative Rearrangement.

David N, Pasceri R, Kitson RR, Pradal A, Moody CJ. David N, et al. Chemistry. 2016 Jul 25;22(31):10867-76. doi: 10.1002/chem.201601605. Epub 2016 Jun 27. Chemistry. 2016. PMID: 27346186

4

A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity.

Xiong R, Zhou W, Siegel D, Kitson RR, Freed CR, Moody CJ, Ross D. Xiong R, et al. Mol Pharmacol. 2015 Dec;88(6):1045-54. doi: 10.1124/mol.115.101451. Epub 2015 Sep 24. Mol Pharmacol. 2015. PMID: 26405178 Free PMC article.

5

19-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity.

Chang CH, Drechsel DA, Kitson RR, Siegel D, You Q, Backos DS, Ju C, Moody CJ, Ross D. Chang CH, et al. Mol Pharmacol. 2014 Jun;85(6):849-57. doi: 10.1124/mol.113.090654. Epub 2014 Mar 28. Mol Pharmacol. 2014. PMID: 24682466 Free PMC article.

6

Toward the total synthesis of hygrocin B and divergolide C: construction of the naphthoquinone-azepinone core.

Nawrat CC, Kitson RR, Moody CJ. Nawrat CC, et al. Org Lett. 2014 Apr 4;16(7):1896-9. doi: 10.1021/ol5003847. Epub 2014 Mar 25. Org Lett. 2014. PMID: 24661134

7

Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90.

Dutton BL, Kitson RR, Parry-Morris S, Roe SM, Prodromou C, Moody CJ. Dutton BL, et al. Org Biomol Chem. 2014 Feb 28;12(8):1328-40. doi: 10.1039/c3ob42211a. Org Biomol Chem. 2014. PMID: 24435512 Free article.

8

An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors--potential therapeutics in cancer and neurodegeneration.

Kitson RR, Moody CJ. Kitson RR, et al. Chem Commun (Camb). 2013 Oct 4;49(76):8441-3. doi: 10.1039/c3cc43457e. Chem Commun (Camb). 2013. PMID: 23770604 Free PMC article.

9

Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.

Kitson RR, Chang CH, Xiong R, Williams HE, Davis AL, Lewis W, Dehn DL, Siegel D, Roe SM, Prodromou C, Ross D, Moody CJ. Kitson RR, et al. Nat Chem. 2013 Apr;5(4):307-14. doi: 10.1038/nchem.1596. Epub 2013 Mar 10. Nat Chem. 2013. PMID: 23511419 Free PMC article.

10

Learning from nature: advances in geldanamycin- and radicicol-based inhibitors of Hsp90.

Kitson RR, Moody CJ. Kitson RR, et al. J Org Chem. 2013 Jun 7;78(11):5117-41. doi: 10.1021/jo4002849. Epub 2013 Mar 26. J Org Chem. 2013. PMID: 23496136

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