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Human β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway.
Peng G, Tsukamoto S, Ikutama R, Nguyen HLT, Umehara Y, Trujillo-Paez JV, Yue H, Takahashi M, Ogawa T, Kishi R, Tominaga M, Takamori K, Kitaura J, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Peng G, et al. Among authors: kitaura j. J Clin Invest. 2022 Sep 1;132(17):e156501. doi: 10.1172/JCI156501. J Clin Invest. 2022. PMID: 35834333 Free PMC article.
The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide.
Izawa K, Yamanishi Y, Maehara A, Takahashi M, Isobe M, Ito S, Kaitani A, Matsukawa T, Matsuoka T, Nakahara F, Oki T, Kiyonari H, Abe T, Okumura K, Kitamura T, Kitaura J. Izawa K, et al. Among authors: kitaura j. Immunity. 2012 Nov 16;37(5):827-39. doi: 10.1016/j.immuni.2012.08.018. Epub 2012 Nov 1. Immunity. 2012. PMID: 23123064 Free article.
Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast cell activation.
Izawa K, Isobe M, Matsukawa T, Ito S, Maehara A, Takahashi M, Yamanishi Y, Kaitani A, Oki T, Okumura K, Kitamura T, Kitaura J. Izawa K, et al. Among authors: kitaura j. J Allergy Clin Immunol. 2014 Jan;133(1):270-3.e1-7. doi: 10.1016/j.jaci.2013.08.008. Epub 2013 Sep 12. J Allergy Clin Immunol. 2014. PMID: 24035150 No abstract available.
Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation.
Shiba E, Izawa K, Kaitani A, Isobe M, Maehara A, Uchida K, Maeda K, Nakano N, Ogawa H, Okumura K, Kitamura T, Shimizu T, Kitaura J. Shiba E, et al. Among authors: kitaura j. J Biol Chem. 2017 Feb 17;292(7):2924-2932. doi: 10.1074/jbc.M116.768366. Epub 2017 Jan 10. J Biol Chem. 2017. PMID: 28073916 Free PMC article.
Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment.
Izawa K, Maehara A, Isobe M, Yasuda Y, Urai M, Hoshino Y, Ueno K, Matsukawa T, Takahashi M, Kaitani A, Shiba E, Takamori A, Uchida S, Uchida K, Maeda K, Nakano N, Yamanishi Y, Oki T, Voehringer D, Roers A, Nakae S, Ishikawa J, Kinjo Y, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J. Izawa K, et al. Among authors: kitaura j. Sci Rep. 2017 Jun 27;7(1):4298. doi: 10.1038/s41598-017-04647-z. Sci Rep. 2017. PMID: 28655892 Free PMC article.
Role of the Ceramide-CD300f Interaction in Gram-Negative Bacterial Skin Infections.
Maehara A, Kaitani A, Izawa K, Shiba E, Nagamine M, Takamori A, Isobe M, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Voehringer D, Roers A, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J. Maehara A, et al. Among authors: kitaura j. J Invest Dermatol. 2018 May;138(5):1221-1224. doi: 10.1016/j.jid.2017.11.025. Epub 2017 Dec 5. J Invest Dermatol. 2018. PMID: 29221685 Free article. No abstract available.
The CD300e molecule in mice is an immune-activating receptor.
Isobe M, Izawa K, Sugiuchi M, Sakanishi T, Kaitani A, Takamori A, Maehara A, Matsukawa T, Takahashi M, Yamanishi Y, Oki T, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Yagita H, Takai T, Ogawa H, Okumura K, Kitamura T, Kitaura J. Isobe M, et al. Among authors: kitaura j. J Biol Chem. 2018 Mar 9;293(10):3793-3805. doi: 10.1074/jbc.RA117.000696. Epub 2018 Jan 22. J Biol Chem. 2018. PMID: 29358324 Free PMC article.
133 results