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A new human adipocyte model with PTEN haploinsufficiency.
Kässner F, Kirstein A, Händel N, Schmid GL, Landgraf K, Berthold A, Tannert A, Schaefer M, Wabitsch M, Kiess W, Körner A, Garten A. Kässner F, et al. Adipocyte. 2020 Dec;9(1):290-301. doi: 10.1080/21623945.2020.1785083. Adipocyte. 2020. PMID: 32579864 Free PMC article.
PTEN regulates adipose progenitor cell growth, differentiation, and replicative aging.
Kirstein AS, Kehr S, Nebe M, Hanschkow M, Barth LAG, Lorenz J, Penke M, Breitfeld J, Le Duc D, Landgraf K, Körner A, Kovacs P, Stadler PF, Kiess W, Garten A. Kirstein AS, et al. J Biol Chem. 2021 Aug;297(2):100968. doi: 10.1016/j.jbc.2021.100968. Epub 2021 Jul 14. J Biol Chem. 2021. PMID: 34273354 Free PMC article.
Altered gene expression profiles impair the nervous system development in individuals with 15q13.3 microdeletion.
Körner MB, Velluva A, Bundalian L, Radtke M, Lin CC, Zacher P, Bartolomaeus T, Kirstein AS, Mrestani A, Scholz N, Platzer K, Teichmann AC, Hentschel J, Langenhan T, Lemke JR, Garten A, Abou Jamra R, Le Duc D. Körner MB, et al. Among authors: kirstein as. Sci Rep. 2022 Aug 5;12(1):13507. doi: 10.1038/s41598-022-17604-2. Sci Rep. 2022. PMID: 35931711 Free PMC article.
The role of rare genetic variants enrichment in epilepsies of presumed genetic etiology.
Bundalian L, Su YY, Chen S, Velluva A, Kirstein AS, Garten A, Biskup S, Battke F, Lal D, Heyne HO, Platzer K, Lin CC, Lemke JR, Le Duc D; Epi25 Collaborative. Bundalian L, et al. Among authors: kirstein as. medRxiv [Preprint]. 2023 Mar 10:2023.01.17.23284702. doi: 10.1101/2023.01.17.23284702. medRxiv. 2023. PMID: 36974069 Free PMC article. Updated. Preprint.
Epilepsies of presumed genetic etiology show enrichment of rare variants that occur in the general population.
Bundalian L, Su YY, Chen S, Velluva A, Kirstein AS, Garten A, Biskup S, Battke F, Lal D, Heyne HO, Platzer K, Lin CC, Lemke JR, Le Duc D; Epi25 Collaborative. Bundalian L, et al. Among authors: kirstein as. Am J Hum Genet. 2023 Jul 6;110(7):1110-1122. doi: 10.1016/j.ajhg.2023.06.004. Epub 2023 Jun 26. Am J Hum Genet. 2023. PMID: 37369202 Free PMC article.
Pten knockout in mouse preosteoblasts leads to changes in bone turnover and strength.
Lorenz J, Richter S, Kirstein AS, Kolbig F, Nebe M, Schulze M, Kiess W, Spitzbarth I, Klöting N, Le Duc D, Baschant U, Garten A. Lorenz J, et al. Among authors: kirstein as. JBMR Plus. 2024 Jan 4;8(3):ziad016. doi: 10.1093/jbmrpl/ziad016. eCollection 2024 Feb. JBMR Plus. 2024. PMID: 38505222 Free PMC article.
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