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Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.
Himmelbauer MK, Bajrami B, Basile R, Capacci A, Chen T, Choi CK, Gilfillan R, Gonzalez-Lopez de Turiso F, Gu C, Hoemberger M, Johnson DS, Jones JH, Kadakia E, Kirkland M, Lin EY, Liu Y, Ma B, Magee T, Mantena S, Marx IE, Metrick CM, Mingueneau M, Murugan P, Muste CA, Nadella P, Nevalainen M, Parker Harp CR, Pattaropong V, Pietrasiewicz A, Prince RJ, Purgett TJ, Santoro JC, Schulz J, Sciabola S, Tang H, Vandeveer HG, Wang T, Yousaf Z, Helal CJ, Hopkins BT. Himmelbauer MK, et al. Among authors: kirkland m. J Med Chem. 2024 May 7. doi: 10.1021/acs.jmedchem.4c00220. Online ahead of print. J Med Chem. 2024. PMID: 38712838
Adeno-Associated Virus-Mediated Dorsal Root Ganglion Toxicity in the New Zealand White Rabbit.
Tien E, Grubor B, Kirkland M, Chan SJ, van der Munnik N, Xu W, Henry K, Hamann S, Wei C, Lee WH, Gianni D, Brennecke A, Nambiar K, Chen J, Liu B, Shen S, Tremblay C, Plowey ED, Trapa P, Fikes J, Suh J, Morris D. Tien E, et al. Among authors: kirkland m. Toxicol Pathol. 2024 Jan;52(1):35-54. doi: 10.1177/01926233241229808. Epub 2024 Feb 22. Toxicol Pathol. 2024. PMID: 38385340
Gut microbiota modulates lung fibrosis severity following acute lung injury in mice.
Chioma OS, Mallott EK, Chapman A, Van Amburg JC, Wu H, Shah-Gandhi B, Dey N, Kirkland ME, Blanca Piazuelo M, Johnson J, Bernard GR, Bodduluri SR, Davison S, Haribabu B, Bordenstein SR, Drake WP. Chioma OS, et al. Among authors: kirkland me. Commun Biol. 2022 Dec 22;5(1):1401. doi: 10.1038/s42003-022-04357-x. Commun Biol. 2022. PMID: 36543914 Free PMC article.
128 results