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Follow-up actions from positive results of in vitro genetic toxicity testing.
Dearfield KL, Thybaud V, Cimino MC, Custer L, Czich A, Harvey JS, Hester S, Kim JH, Kirkland D, Levy DD, Lorge E, Moore MM, Ouédraogo-Arras G, Schuler M, Suter W, Sweder K, Tarlo K, van Benthem J, van Goethem F, Witt KL. Dearfield KL, et al. Among authors: kirkland d. Environ Mol Mutagen. 2011 Apr;52(3):177-204. doi: 10.1002/em.20617. Epub 2010 Oct 20. Environ Mol Mutagen. 2011. PMID: 20963811 Free article. Review.
Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations.
Dearfield KL, Gollapudi BB, Bemis JC, Benz RD, Douglas GR, Elespuru RK, Johnson GE, Kirkland DJ, LeBaron MJ, Li AP, Marchetti F, Pottenger LH, Rorije E, Tanir JY, Thybaud V, van Benthem J, Yauk CL, Zeiger E, Luijten M. Dearfield KL, et al. Environ Mol Mutagen. 2017 Jun;58(5):264-283. doi: 10.1002/em.22045. Epub 2016 Sep 21. Environ Mol Mutagen. 2017. PMID: 27650663 Review.
Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? I. Reports of individual databases presented at an EURL ECVAM Workshop.
Kirkland D, Zeiger E, Madia F, Gooderham N, Kasper P, Lynch A, Morita T, Ouedraogo G, Parra Morte JM, Pfuhler S, Rogiers V, Schulz M, Thybaud V, van Benthem J, Vanparys P, Worth A, Corvi R. Kirkland D, et al. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:55-68. doi: 10.1016/j.mrgentox.2014.10.005. Epub 2014 Oct 23. Mutat Res Genet Toxicol Environ Mutagen. 2014. PMID: 25435356 Free article.
Strategy for genotoxicity testing: hazard identification and risk assessment in relation to in vitro testing.
Thybaud V, Aardema M, Clements J, Dearfield K, Galloway S, Hayashi M, Jacobson-Kram D, Kirkland D, MacGregor JT, Marzin D, Ohyama W, Schuler M, Suzuki H, Zeiger E; Expert Working Group on Hazard Identification and Risk Assessment in Relation to In Vitro Testing. Thybaud V, et al. Among authors: kirkland d. Mutat Res. 2007 Feb 3;627(1):41-58. doi: 10.1016/j.mrgentox.2006.10.003. Epub 2006 Nov 27. Mutat Res. 2007. PMID: 17126066
Relationships between p53 status, apoptosis and induction of micronuclei in different human and mouse cell lines in vitro: Implications for improving existing assays.
Whitwell J, Smith R, Jenner K, Lyon H, Wood D, Clements J, Aschcroft-Hawley K, Gollapudi B, Kirkland D, Lorge E, Pfuhler S, Tanir JY, Thybaud V. Whitwell J, et al. Among authors: kirkland d. Mutat Res Genet Toxicol Environ Mutagen. 2015 Aug;789-790:7-27. doi: 10.1016/j.mrgentox.2015.05.011. Epub 2015 May 30. Mutat Res Genet Toxicol Environ Mutagen. 2015. PMID: 26232254
Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay.
Bryce SM, Bernacki DT, Bemis JC, Spellman RA, Engel ME, Schuler M, Lorge E, Heikkinen PT, Hemmann U, Thybaud V, Wilde S, Queisser N, Sutter A, Zeller A, Guérard M, Kirkland D, Dertinger SD. Bryce SM, et al. Among authors: kirkland d. Environ Mol Mutagen. 2017 Apr;58(3):146-161. doi: 10.1002/em.22083. Environ Mol Mutagen. 2017. PMID: 28370322 Free PMC article.
Workshop summary: Top concentration for in vitro mammalian cell genotoxicity assays; and report from working group on toxicity measures and top concentration for in vitro cytogenetics assays (chromosome aberrations and micronucleus).
Galloway S, Lorge E, Aardema MJ, Eastmond D, Fellows M, Heflich R, Kirkland D, Levy DD, Lynch AM, Marzin D, Morita T, Schuler M, Speit G. Galloway S, et al. Among authors: kirkland d. Mutat Res. 2011 Aug 16;723(2):77-83. doi: 10.1016/j.mrgentox.2011.01.003. Epub 2011 Jan 19. Mutat Res. 2011. PMID: 21255675
A comparison of transgenic rodent mutation and in vivo comet assay responses for 91 chemicals.
Kirkland D, Levy DD, LeBaron MJ, Aardema MJ, Beevers C, Bhalli J, Douglas GR, Escobar PA, Farabaugh CS, Guerard M, Johnson GE, Kulkarni R, Le Curieux F, Long AS, Lott J, Lovell DP, Luijten M, Marchetti F, Nicolette JJ, Pfuhler S, Roberts DJ, Stankowski LF Jr, Thybaud V, Weiner SK, Williams A, Witt KL, Young R. Kirkland D, et al. Mutat Res Genet Toxicol Environ Mutagen. 2019 Mar;839:21-35. doi: 10.1016/j.mrgentox.2019.01.007. Epub 2019 Jan 18. Mutat Res Genet Toxicol Environ Mutagen. 2019. PMID: 30744809 Free PMC article.
Improvement of in vivo genotoxicity assessment: combination of acute tests and integration into standard toxicity testing.
Rothfuss A, Honma M, Czich A, Aardema MJ, Burlinson B, Galloway S, Hamada S, Kirkland D, Heflich RH, Howe J, Nakajima M, O'Donovan M, Plappert-Helbig U, Priestley C, Recio L, Schuler M, Uno Y, Martus HJ. Rothfuss A, et al. Among authors: kirkland d. Mutat Res. 2011 Aug 16;723(2):108-20. doi: 10.1016/j.mrgentox.2010.12.005. Epub 2010 Dec 21. Mutat Res. 2011. PMID: 21182982
150 results