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963 results

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Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans.
Finan B, Ma T, Ottaway N, Müller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, Lockie SH, Smiley DL, Gelfanov V, Yang B, Hofmann S, Bruemmer D, Drucker DJ, Pfluger PT, Perez-Tilve D, Gidda J, Vignati L, Zhang L, Hauptman JB, Lau M, Brecheisen M, Uhles S, Riboulet W, Hainaut E, Sebokova E, Conde-Knape K, Konkar A, DiMarchi RD, Tschöp MH. Finan B, et al. Among authors: kirchner h. Sci Transl Med. 2013 Oct 30;5(209):209ra151. doi: 10.1126/scitranslmed.3007218. Sci Transl Med. 2013. PMID: 24174327 Clinical Trial.
Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure.
Pfluger PT, Kirchner H, Günnel S, Schrott B, Perez-Tilve D, Fu S, Benoit SC, Horvath T, Joost HG, Wortley KE, Sleeman MW, Tschöp MH. Pfluger PT, et al. Among authors: kirchner h. Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G610-8. doi: 10.1152/ajpgi.00321.2007. Epub 2007 Nov 29. Am J Physiol Gastrointest Liver Physiol. 2008. PMID: 18048479 Free article.
GOAT links dietary lipids with the endocrine control of energy balance.
Kirchner H, Gutierrez JA, Solenberg PJ, Pfluger PT, Czyzyk TA, Willency JA, Schürmann A, Joost HG, Jandacek RJ, Hale JE, Heiman ML, Tschöp MH. Kirchner H, et al. Nat Med. 2009 Jul;15(7):741-5. doi: 10.1038/nm.1997. Epub 2009 Jun 5. Nat Med. 2009. PMID: 19503064 Free PMC article.
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.
Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschöp MH. Day JW, et al. Among authors: kirchner h. Nat Chem Biol. 2009 Oct;5(10):749-57. doi: 10.1038/nchembio.209. Epub 2009 Jul 13. Nat Chem Biol. 2009. PMID: 19597507
GOAT: the master switch for the ghrelin system?
Romero A, Kirchner H, Heppner K, Pfluger PT, Tschöp MH, Nogueiras R. Romero A, et al. Among authors: kirchner h. Eur J Endocrinol. 2010 Jul;163(1):1-8. doi: 10.1530/EJE-10-0099. Epub 2010 Apr 26. Eur J Endocrinol. 2010. PMID: 20421334 Review.
Induction of ketosis in rats fed low-carbohydrate, high-fat diets depends on the relative abundance of dietary fat and protein.
Bielohuby M, Menhofer D, Kirchner H, Stoehr BJ, Müller TD, Stock P, Hempel M, Stemmer K, Pfluger PT, Kienzle E, Christ B, Tschöp MH, Bidlingmaier M. Bielohuby M, et al. Among authors: kirchner h. Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E65-76. doi: 10.1152/ajpendo.00478.2010. Epub 2010 Oct 13. Am J Physiol Endocrinol Metab. 2011. PMID: 20943751 Free article.
Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor.
Barnett BP, Hwang Y, Taylor MS, Kirchner H, Pfluger PT, Bernard V, Lin YY, Bowers EM, Mukherjee C, Song WJ, Longo PA, Leahy DJ, Hussain MA, Tschöp MH, Boeke JD, Cole PA. Barnett BP, et al. Among authors: kirchner h. Science. 2010 Dec 17;330(6011):1689-92. doi: 10.1126/science.1196154. Epub 2010 Nov 18. Science. 2010. PMID: 21097901 Free PMC article.
963 results